IL-6 antagonist peptides

Details IL-6 antagonist peptides IL-6 antagonist peptides

2005-01-04

2005-01-04

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S015800, C514S016700, C530S300000, C530S350000, C530S326000, C530S327000, C530S328000, C424S085200

Reexamination Certificate

active

06838433

ABSTRACT:
The present invention relates to IL-6 antagonist peptides, isolatable from a peptide library through the two-hybrids system by their ability to bind to the intracellular domain of gp130 and containing at least 5 amino acids. In particular, such peptides comprise the amino acid sequence SEQ ID NO: 6, as well as salts, functional derivatives, precursors and analogs thereof. The present invention also provides the peptides in substantially purified form, in order to be suitable for use in pharmaceutical compositions as active ingredient in pathologies that require IL-6 activity inhibition.

REFERENCES:
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patent: 6004813 (1999-12-01), Serupi-Crescenzi et al.
patent: 6599875 (2003-07-01), Serlupi-Crescenzi et al.
patent: WO 9713781 (1997-04-01), None
patent: WO 9748728 (1997-12-01), None
patent: WO 9960013 (1999-11-01), None
Dittrich et al., Identification of a Region within the Cytoplasmic Domain of the Interleukin-6 (IL-6) Signal Transducer gp130 Important for Ligand-induced Endocytosis of the IL-6 Receptor, J. Biol. Chem. 269, 19014-19020 (1994).*
Narazaki et al., Soluble Forms of the Interleukin-6 Signal-Transducing Receptor Component gp130 in Human Serum Processing a Potential to Inhibit Signals Through membrane-Anchored gp130, Blood 82 (4) 1120-1126 (1993).*
Murakami et al. Critical Cytoplasmic Region of the Interleukin 6 Signal Transducer gp130 Is conserved in the Cytokine Receptor Family, Proc. natl. Acad. Sci. USA 88, 11349-11353 (1991).

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