IL-5 targeted ribozymes

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 9131, 4353201, 435325, 536 231, 536 232, 536 245, 514 44, C12N 1505, C12Q 168, A61K 4800

Patent

active

056164882

ABSTRACT:
Enzymatic RNA molecules which cleave IL-5 mRNA.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5334711 (1994-08-01), Sproat et al.
Koizumi et al. Gene 117:179 (1992).
Tanabe et al. J. Biol. Chem. 262:16580 (1987).
Stull et al. Pharm. Res. 12:465 (1995).
Barinaga, Science 262:1512-1514 (1993).
Carter, "Adeno-Associated Virus Vectors," Curr Opi. Biotech. 3:533-539 (1992).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030-3034 (1988).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Cook and Spicer, "Ch. 10 - Animal Models of Eosinophilia" in Immunopharmacol. Eosinophils ed. Smith and Cook eds., Academic, London U.K., pp. 193-216 (1993).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Gleich, "The eosinophil and bronchial asthma: Current understanding," J. Allergy Clin. Immunol. 85:422-436 (1990).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme, " Cell 35:849-857 (1983).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hertel et al., "Numbering System for the Hammerhead," Nucleic Acids Res. 20:3252 (1992).
Hession et al., WO 9013300 provided as Chem Abstr. Acc # 114(25)-242037g.
Jaeger et al., "Improved Predictions of Secondary Structures for RNA," Proc. Natl. Acad. Sci. USA 86:7706-7710 (1989).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Johnston and Hoth, Science 260:1286-1293 (1993).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kay, "Asthma and Inflammation," J. Allergy Clin. Immun. 87:893-910 (1991).
Kim and Cech, "Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena," Proc. Natl. Acad. Sci. USA 84:8788 (1987).
Koike and Takatsu, "IL and Its Receptor: Which Role Do They Play in the Immune Response?" Int. Arch. Allergy. Immunol. 104:1-9 (1994).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Mamone et al., "Design of Mannerhead Ribozymes Targeted to Sequences in HIV, HSV, and the RAT ANF GENE," Abstract of Keystone, CO (May, 27, 1992).
Nabel et al., "Site-Specific Gene Expression in Vivo by Direct Gene Transfer Into the Arterial Wall," Science 249:1285-1288 (1990).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
Perreault et al., "Mixed Deoxyribo- and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Rossi et al., "Ribozyme Mediated Intracellular Immunity to HIV-1 in CD4," J. Cell Biochem. Suppl 14A:D428 (1990).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183-189 (1992).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Saville and Collins, "A Site-Specific Self-Cleavage Reaction Performed by a Novel RNA In Neurospora Mitochondria," Cell 61:685-696 (1990).
Saville and Collins, "RNA-Mediated Ligation of Self-Cleavage Products of a Neurospora Mitochondrial Plasmid Transcript," Proc. Natl. Acad. Sci. USA 88:8826-8830 (1991).
Scanlon et al., "Ribozyme-Mediated Cleavage of c-fos mRNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein," Proc. Natl. Acad. Sci. USA 88:10591-10595 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Sioud et al., J. Mol. Biol. 223:831-835 (1992).
Taira et al., "Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors," Nucleic Acids Research 19:5125-5130 (1991).
Tanabe et al., J. Biol. Chem. 262:16580 (1987) provided as BIOSIS Abstr. 85047487.
Uhlenbeck, "A Small Catalytic Oligoribonucleotide," Nature 328:596-600 (1987).
Usman et al.,"Automated Chemical Synthesis or Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3'-Half Molecule of an Escherichia coli Formylmethoionine tRNA," J. Am. Chem. Soc. 109:7845-7854 (1987).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
van Oosterhout et al., "Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs," Am. Rev. Respir. Dis. 147:548-552 (1993).
Varga et al., "L-Tryptophan and the Eosinophilia-Myalgia Syndrome: Current Understanding of the Etiology and Pathogenesis," J. Invest. Dermatol. 100:97s-105S (1993).
Ventura et al., "Activation of HIV-Specific Ribozyme Activity by Self-Cleavage," Nucleic Acids Research 21:3249-3255 (1993).
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vetors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65:5531-5534 (1994).
Willard et al., "Recombinant Adenovirus in an Efficient Vector for In Vivo Gene Transfer and can be Preferentially Directed at Vascular Endothelium or Smooth Muscle Cells," Circulation - Abstracts from the 6th Scientific Sessions, New Orleans Convention Center, New Orleans, Louisiana, Nov. 16-19, 1992, 86:I-473 at 1880.
Woolf et al., "Specificity of Antisense Oligonucleotides in vivo," Proc. Natl. Acad. Sci. USA 89:7305-7309 (1992).
Yu et al., "A Hairpin Ribozyme Inhibits Expression of Diverse Strains of Hu

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

IL-5 targeted ribozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with IL-5 targeted ribozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and IL-5 targeted ribozymes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-538339

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.