Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2007-03-06
2007-03-06
O'Hara, Eileen (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C435S069100, C514S012200, C536S023500
Reexamination Certificate
active
11174398
ABSTRACT:
The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC50that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of IL-21 with its cognate receptor.
REFERENCES:
patent: 6307024 (2001-10-01), Novak et al.
patent: 6605272 (2003-08-01), Novak et al.
patent: 6686178 (2004-02-01), Novak et al.
patent: 00/53761 (2000-09-01), None
patent: 03/087320 (2003-10-01), None
1483966, Marra, WashU-HHMI Mouse EST Project, 1996.
Brandt et al., “Generation of Antagonists by Amino Acid Replacement in the D-Helix of Human IL-21,” : abs. 119, 2001.
Parrish-Novak et al., “Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function,”Nature 408:57-63, 2000.
Parrish-Novak et al., “Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses,”J. of Leukocyte Biol., 72:856-863, 2002.
Novak Julia E.
Presnell Scott R.
West James W.
Hamud Fozia
O'Hara Eileen
Savislak Deborah A.
ZymoGenetics Inc.
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