Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-02-28
1992-10-06
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 435 6952, C07K 1300
Patent
active
051533103
ABSTRACT:
Biologically active analogs of human IL2, which differ from natural IL2 by the substitution of amino acid residues to form N-linked glycosylation sites in the molecule, are prepared by recombinant DNA techniques. Such analogs of IL2 are N-linked glycosylated when expressed in eukaryotic cells. Natural IL2 is not N-linked glycosylated.
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Hofer et al., Biol. Chem. Hoppe Seyler 368(9):1060 (1987).
Ju et al., J. Biol. Chem. 262:5723-5731 (1987).
Liang et al., J. Biol. Chem. 261:334-337 (1986).
Cohen et al., Science 234:349-352 (1986).
Wang et al., Science 224:1431-1433 (1984).
Bio-Rad Catalog No. 170-3571.
Kunkel Proc. Natl. Acad. Sci. 82:488-492 (1985).
Ferrara et al., FEBS 226(1), pp. 47-52 (1987).
Mitchell Kenneth F.
Vallone Carol A.
Du Pont Merck Pharmaceutical Company
Ferguson Blair Q.
Guest Shelly J.
Kerr Don M.
Lacey David L.
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