IL-2 analogs containing N-linked glycosylation sites

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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530395, 435 6952, C07K 1300

Patent

active

051533103

ABSTRACT:
Biologically active analogs of human IL2, which differ from natural IL2 by the substitution of amino acid residues to form N-linked glycosylation sites in the molecule, are prepared by recombinant DNA techniques. Such analogs of IL2 are N-linked glycosylated when expressed in eukaryotic cells. Natural IL2 is not N-linked glycosylated.

REFERENCES:
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Ju et al., J. Biol. Chem. 262:5723-5731 (1987).
Liang et al., J. Biol. Chem. 261:334-337 (1986).
Cohen et al., Science 234:349-352 (1986).
Wang et al., Science 224:1431-1433 (1984).
Bio-Rad Catalog No. 170-3571.
Kunkel Proc. Natl. Acad. Sci. 82:488-492 (1985).
Ferrara et al., FEBS 226(1), pp. 47-52 (1987).

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