IL-18 transgenic animal

Details IL-18 transgenic animal IL-18 transgenic animal

2006-08-29

2006-08-29

Wehbe', Anne M. (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S009000, C800S018000, C800S021000

Reexamination Certificate

active

07098373

ABSTRACT:
Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings.The transgenic non-human mammals according to the present invention spontaneously develop atopic dermatitis under specific pathogen-free conditions, and therefore, are useful as disease model animals. Use of the transgenic non-human mammals according to the present invention makes it possible to develop drugs for preventing or treating atopic dermatitis by natural immunity and also to elucidate the onset mechanisms of atopic diseases.

REFERENCES:
patent: 01/95710 (2001-12-01), None
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Yamanaka K. et al., “Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition With a High Serum Level of IL-181”. The Journal of Immunology,vol. 165, pp. 997-1003 2000.
Hoshino T. et al., “Cutting Edge: IL-18-Transgenic Mice: In Vivo Evidence of a Broad Role for IL-18 in Modulating Immune Function”. The Journal of Immunology, vol. 166, pp. 7014-7018 Jun. 15, 2001.
Osaki T. et al., “Potent antitumor effects mediated by local expression of the mature form of the Interferon-γ inducing factor, Interleukin-18(IL-18).” Gene Therapy, vol. 6, pp. 808-815 1999.
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Yamanaka K. et al., “Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-endotoxin Shock Condition With a High Serum Level of IL-181”. The journal of Immunology, vol. 165, pp. 997-1003 2000.
Tomohiro Yoshimoto, et al., “IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6”, Nature Immunology, vol. 1, No. 2, Aug. 2000, pp. 132-137.

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