Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-06-28
2011-06-28
Kemmerer, Elizabeth C. (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388100, C530S388230, C530S391300, C530S391700, C424S130100, C424S133100, C424S145100, C424S178100, C435S069100, C435S320100, C435S069700, C435S325000, C435S326000, C435S328000, C435S335000, C435S348000, C435S349000, C435S358000, C435S365000, C435S365100, C435S410000, C435S419000, C435S252300, C435S252330, C435S254110, C435S254210, C536S023100, C536S023400, C536S023500, C536S023530
Reexamination Certificate
active
07968684
ABSTRACT:
The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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Babcook John
Ghayur Tariq
Green Larry
Hedberg Brad
Jia Xiao-Chi
Abbott Laboratories
Gulati, Esq. Maneesh
Kemmerer Elizabeth C.
Laccotripe Zacharakis Maria
McCarter & English LLP
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