IL-16 antagonist peptides and DNA encoding the peptides

Details IL-16 antagonist peptides and DNA encoding the peptides IL-16 antagonist peptides and DNA encoding the peptides

2007-04-24

2007-04-24

Bunner, Bridget (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C514S016700, C514S017400, C530S326000, C530S328000, C530S329000, C530S330000, C536S023500

Reexamination Certificate

active

10358627

ABSTRACT:
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acids in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.

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