Il-15 triplex oligonucleotides

Details Il-15 triplex oligonucleotides Il-15 triplex oligonucleotides

1996-10-25

1999-02-23

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 536 2433, 435 6, 435 911, C07H 2104, C12Q 168

Patent

active

058745661

ABSTRACT:
Oligomers for inhibiting expression of interleukin genes are described. It is believed that each oligomer, when introduced into a cell, is capable of forming a transcription-inhibiting complex composed of the oligomer and an interleukin gene. The oligomer preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the interleukin gene.

REFERENCES:
McInnes et al.; The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis; Nature Medicine, vol. 2, No. 2, Feb. 1996, pp. 175-182.
Edelbaum et al.; Interleukin (IL)-15 Promotes the Growth of Murine Epidermal Y.delta. T Cells by a Mechanism Involving the .beta.- and .gamma..sub.c -Chains of the IL-2 Receptor; J. Invest. Dermatol., 105:837-843 (1995).
Durland et la.; Binding of Triple Helix Forming Oligonucleotides to Sites in Gene Promoters; Biochemistry, 30:9246-9255 (1991).
Blauvelt et al.; Interleukin-15 mRNA is Expressed by Human Keratinocytes, Langerhans Cells, and Blood-Derived Dendritic Cells and is Downregulated by Ultraviolet B Radiation; J. Invest. Dermatol. 106:1047-1052 (1996).
Young et al.; Triple helix formation inhibits transcription elongation in vitro; Proc. Natl. Acad. Sci, 88:10023-10026 (1991).
Tu et al.; Inhibition of Gene Expression by Triple Helix Formation in Hepatoma Cells; J. Biol. Chem., 270:28402-28407 (1995).
Faucon et al.; Effect of third strand composition on triple helix formation: purine versus pyrimidine oligodeoxynucleotides; Nucleic Acids Research, 24:3181-3188 (1996).
Kovacs et al.; Triple Helix-forming Oligonucleotide Corresponding to the Polypyrimidine Sequence in the Rat .alpha.1(I) Collagen Promoter Specifically Inhibits Factor Binding and Transcpription; J. Biol. Chem; 271:1805-1812 (1996).
Rando et al.; Inhibition of T7 and T3 RNA polymerase directed transcription elongation in vitro; Nucleic Acids Research; 22:678-685 (1994).
Mori et al.; IL-15 Promotes Cytokine Production of Human T Helper Cells; J. Immunol. 156:2400-2405 (1996).
R. Stoll et al. Pharm. Res. 12(4) 465-483, 1995.
Genesis Group Assoc. Inc.--IAC Newsletter, Dialog File 636, Abs. #01997756, 1993.
Salemo et al. Immunol. 84: 404-9, 1995.
Grabstein et al. Science 264: 965-8, 1994.
Asseline et al. PNAS 81: 3297-3301, 1984.
Hanvey et al. Science 258 1481-5, 1992.
Genbank Accession # Vo3099, via STN/Genbank database, 1994.
M. Grigoriev et al J. Biol. Chem. 267(5) 3389-95, 1992.
E. Pastel et al. P.N.A.S. 88:8227-31, 1991.
F. Orson et al. Nucl. Acids Res. 19(12) 3435-41, 1991.
W. McShan et al. J. Biol. Chem. 267(8):5712-21, 1992.
L.J. Maker III et al. Bio Essays 14(12)807-815, 1992.
E. Uhlmann et al. Chem. Rev. 90(4): 543-584, 1990.
J. Milligan et al. J. Med. Chem. 36(14):1923-37, 1993.
C. Stein et al. Science 261: 1004-12, 1993.

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