IL-15 mutants having agonists/antagonists activity

Details IL-15 mutants having agonists/antagonists activity IL-15 mutants having agonists/antagonists activity

2005-02-10

2010-12-28

Jiang, Dong (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C530S351000

Reexamination Certificate

active

07858081

ABSTRACT:
The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

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