IL-13 production inhibitor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S007200, C436S501000, C436S503000

Reexamination Certificate

active

07951548

ABSTRACT:
The present invention provides a screening method/screening kit for an IL-13 production inhibitor, which comprises using (a) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a salt thereof; and (b) a ligand capable of specifically binding to the protein; an IL-13 production inhibitor which is obtainable by said screening, and the like. The IL-13 production inhibitor which can be obtained by the screening of the present invention is useful as a prophylactic/therapeutic agent for, e.g., respiratory disease, etc.

REFERENCES:
patent: 1455186 (2004-09-01), None
patent: 2005-325055 (2005-11-01), None
patent: WO-03-052414 (2003-06-01), None
patent: WO-2005-028667 (2005-03-01), None
Aoki et al, Biochimica et Biophysica Acta, 2002, vol. 1582, pp. 26-32.
Wells, 1990, Biochemistry 29:8509-8517.
T. Sugo, et al., “Identification of a lysophosphatidylserine receptor on mast cells”Biochem. Biophys. Res. Commun., vol. 341, No. 4, p. 1078-1087 (Mar. 24, 2006).
A. Schulz, et al., “The structural evolution of a P2Y-like G-protein-coupled receptor,” J. Biol. Chem., vol. 278, No. 37, p. 35531-35541 (2003).

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