Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-11-12
2000-11-07
Kemmerer, Elizabeth
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530300, 536 235, 536 231, 435 71, 435 691, 314 2, C07K 1400, A61K 3802, A61K 3817, C07H 2104
Patent
active
061438715
ABSTRACT:
Polypeptides capable of binding human IL-13 and/or of binding human IL-4 in the presence of IL-4 R.alpha. can be used in medicine, in diagnosis and in screening for agonists/antagonists of IL-13/IL-4. One such polypeptide is shown in FIG. 1.
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Bowie et al., Deciphering the message in Protein sequences: Tolerance to Amino Acid Substitutions. Science, vol. 247, pp. 1306-1310, 1990.
Wells, J. A et al., Additivity of mutational effects in proteins, Biochemistry, pp. 8509-8579, 1990.
Caput et al, "Cloning and Characterization of a Specific Interleukin (IL)-13 Binding Protein Structurally Related to the IL-5 Receptor .alpha. Chain", The Journal of Biological Chemistry 271(28):16921-16926 (1996).
Minty et al, "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses", Nature 362:248-250 (1993).
Aman et al, "cDNA Cloning and Characterization of the Human Interleukin 13 Receptor .alpha. Chain", The Journal of Biological Chemistry, 271(46):29265-29270 (1996).
Hilton et al, "Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor", Proc. Natl. Acad. Sci. USA 93:497-501 (1996).
Callard et al, "IL-4 and IL-13 receptors: are they one and the same?", Immunology Today 17(3):108-110 (1996).
Bonnefoy Jean-Yves
Gauchat Jean-Fran.cedilla.ois
Basi Nirmaz S.
Kemmerer Elizabeth
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