Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1998-03-05
1999-11-16
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 854, 4241841, 4241911, 4242041, 4242341, 4242641, 4242691, 530350, A61K 4505, A61K 3900
Patent
active
059852640
ABSTRACT:
The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-.gamma. (IFN-.gamma.) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.
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Arulanandam Bernard P.
Metzger Dennis W.
Eisenschenk Frank C.
Salimi Ali R.
The Medical College of Ohio
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