IL-12 inhibition of B1 cell activity

Details IL-12 inhibition of B1 cell activity IL-12 inhibition of B1 cell activity

1995-02-02

1997-09-09

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 12, 514 21, A61K 3820, A61K 4505

Patent

active

056653476

ABSTRACT:
The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity.

REFERENCES:
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Jamin, C., et al., "Expression of CD5 and CD72 on T and B Cell Subsets in Rheumatoid Arthritis and Sjoegren's Syndrome", Clin. Exp. Immunology, 92(2):245-250 (1993).
Stall, A.M., et al., "LY-1 B-Cell Clones Similar to Human Chronic Lymphocytic Leukemias Routinely Develop in Older Normal Mice and Young Autoimmune (New Zealand Black-Related) Animals)", PNAS, USA, 85:7312-7316 (1988).
Chizzonite, R., et al., "Initial Characterization of the IL-12 Receptor (IL-12R) on Concanavalin-A Activated Mouse Spenocytes", J. Cell Biochemistry, Suppl., 0(17) Part B:73, NY, NY (1993).
Metzger, D.W., et al., "The Effects of IL12 on B-Cell Subset Function", Research in Immunology, 146(7-8):499-505, Paris, France (1995).
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Li, L., et al., "Recombinant human natural killer cell stimulating factor is a human B cell growth factor", Faseb J., 5:A1090 (1991) (Abstract).
Jelinek, D.F. and Braaten, J.K., "Role of IL-12 in human B lymphocyte proliferation and differentiation", J. of Immunol., 154:1606-1613 (1995).
Kiniwa, M., et al., "Recombinant Interleukin-12 Suppresses the Synthesis of Immunoglobulin E by Interleukin-4 Stimulated Human Lymphocytes", J. Clin. Invest., 90:262-266 (Jul. 1992).
Trinchieri, G., "Interleukin-12: A Cytokine Produced by Antigen-Presenting Cells With Immunoregulatory Functions in the Generation of T-Helper Cells Type 1 and Cytotoxic Lymphocytes", Blood, 84(12):4008-4027 (Dec. 15, 1994).
Morris, S.C., et al., "Effects of IL-12 on in Vivo Cytokine Gene Expression and Ig Isotype Selection", J. of Immunol., 152:1047-1056 (1994).
Desai, B.B., et al., "Il-12 Receptor", J. of Immunol., 148(10):3125-3132 (May 15, 1992).
Gemmell et al: `Cytokines and T Cell Switching`, Critical Reviews in Oral Biology and Medicine, vol. 5(314), pp. 249-279, 1994.

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