Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Reexamination Certificate
2011-08-09
2011-08-09
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
C424S085100, C514S021200, C530S402000
Reexamination Certificate
active
07993637
ABSTRACT:
The present invention relates generally to the treatment of an interleukin-11 (IL-11)-mediated condition. More particularly, the present invention provides the use of modified forms of IL-11 which modulate IL-11 signaling in the treatment of IL-11-mediated conditions.
REFERENCES:
patent: WO 03/099322 (2003-12-01), None
patent: WO 2005/014643 (2005-02-01), None
Nicholas Underhill-Day et al., “Functional Characterization of W147A: A High-Affinity Interleukin-11 Antagonist,” Endocrinology 144(8):3406-14 (2003).
Czupryn, M., et al., “Alanine-scanning Mutagenesis of Human Interleukin-11: Identification of Regions Important for Biological Activity”, Annals of the New York Academy of Sciences, vol. 762, pp. 152-164 (1995).
Barton, V., et al. “Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11”, Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, Inc., U.S., vol. 274, No. 9, pp. 5755-5761 (1999).
Tacken, I., et al., “Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis”, European Journal of Biochemistry, vol. 265, No. 2, pp. 645- 655 (1999).
International Search Report mailed Jan. 7, 2009 in connection with PCT International Application No. PCT/AU2008/001587 filed Oct. 24, 2008.
Extended European Search Report dated Dec. 30, 2010 in connection with European Patent Application No. 08842066.
CSL Limited
Mertz Prema
Scully , Scott, Murphy & Presser, P.C.
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