Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-06-06
2000-06-27
Spector, Lorraine
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 231, 536 2431, 4353201, 435325, 4352523, 43525411, 435194, 530350, C12N 1500
Patent
active
060805579
ABSTRACT:
Purified and isolated IL-1/TNF-.alpha.-activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.
REFERENCES:
Callard et al, The Cytokine FactsBook, Academic Press Ltd, 1994, p. 31.
Fujiwara et al, EST, Genbank Accession No. D63222, May 1996.
Guesdon et al., "Interleukin 1 and Tumor Necrosis Factor Stimulate Two Novel Protein Kinases That Phosphorylate the Heat Shock Protein hsp27 and .beta.-Casein," Journal of Biological Chemistry 268(6): 4236-4243, 1993.
Guesdon et al., "Specific activation of .beta.-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor," Biochem. Journal 304: 761-768, 1994.
Guesdon et al., ".beta.-Casein Kinase: Exclusive Activation By IL-1 or TNF and Substrate Specificity," Cytokine 6(5): 558, Abstract No. A119, 1994.
Guesdon et al., "Substrate Specificity of the IL1- and TNF- Activated .beta. Casein Kinase," Cytokine 7: 603, Abstract No. A48, 1995.
Letwin et al., "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells," EMBO Journal 11(10): 3521-3531, 1992.
McLaughlin et al., "Identification of Mitogen-activated Protein (MAP Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase," Journal of Biological Chemistry 271(14): 8488-8492, 1996.
Saklatvala et al., "Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction," Phil. Trans. R. Soc. Lond. B 351: 151-157, 1996.
Anderson Dirk M.
Bird Timothy A.
Sims John E.
Virca G. Duke
Immunex Corporation
Lazar-Wesley Eliane
Smith Julie K.
Spector Lorraine
LandOfFree
IL-1/TNF-.alpha.-activated kinase (ITAK), and methods of making does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with IL-1/TNF-.alpha.-activated kinase (ITAK), and methods of making , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and IL-1/TNF-.alpha.-activated kinase (ITAK), and methods of making will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1783176