Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-04-25
1996-04-23
Walsh, Stephen G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 852, 930141, 435 6952, C07K 14545
Patent
active
055104622
ABSTRACT:
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes-stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
REFERENCES:
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Auron Philip E.
Dinarello Charles A.
Rich Alexander
Webb Andrew C.
Wolff Sheldon M.
Massachusetts Institute of Technology
New England Medical Centers Hospitals, Inc.
Spector L.
Trustees of Tufts College
Walsh Stephen G.
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