IL-1.alpha. derivatives and medicament for treating thrombocytop

Details IL-1.alpha. derivatives and medicament for treating thrombocytop IL-1.alpha. derivatives and medicament for treating thrombocytop

1989-07-28

1992-06-09

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 530351, 435 6952, A61K 3702

Patent

active

051205343

ABSTRACT:
The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

REFERENCES:
Nakai et al., Life Sciences, vol. 45, 1989, pp. 585-591.
Broudy et al., J. Immunol., 139, 1987, pp. 464-468.
Tewari et al., Lancet, 336, 1990, pp. 712-714 (abstract only).
Tanikawa et al., Exp. Hematol., 17, 1989, pp. 883-888.
Morstyn et al., J. Clinical Oncology, 7, 1989, pp. 1554-1562.
Kojima et al., J. Cell. Physiol., 138(1), 1989, 192-6 (abstract only).
"Biology of Interleukin 1", by C. A. Dinarello, The FASEB Journal, vol. 2, No. 2, Feb. 2, 1988, pp. 108-115.
Biological Abstract No. 87089555, by E. Bruno et al.; 73 (3), 1989.

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