IL-1.alpha. derivatives

Details IL-1.alpha. derivatives IL-1.alpha. derivatives

1994-06-06

1998-05-26

Kemmerer, Elizabeth C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 435 6952, C07K 1454

Patent

active

057566755

ABSTRACT:
The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

REFERENCES:
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patent: 5017692 (1991-05-01), Zurawski et al.
patent: 5047505 (1991-09-01), Huang
patent: 5093242 (1992-03-01), Bachman et al.
Wells. Biochemistry 29:8509-8517, Sep. 1990.
Bowie et al, Science, 247 1990, pp. 1306-1310.
Masley et al, PNAS 84, 1987, pp. 4572-4576.
Wingfield et al, Prot. Engineering 1(5) 1987, pp. 413-417.
Gronenborn et al, FEBS 231(1) 1988, pp. 135-138.
Mac Donald et al, FEBS 209(2) 1986, pp. 295-298.
Daumy et al Brochem Biophys Oct. 1989, pp. 32-42, vol. 998.
Zucali et al, Exp Hematul. 18, 1990, pp. 1078-1082.

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