IKK-αproteins, nucleic acids and methods

Details IKK-αproteins, nucleic acids and methods IKK-αproteins, nucleic acids and methods

2006-05-16

2006-05-16

Patterson, Jr., Charles L (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S252300

Reexamination Certificate

active

07045613

ABSTRACT:
The invention provides methods and compositions relating to an IκB kinase, IKK-α, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-α encoding nucleic acids or purified from human cells. The invention provides isolated IKK-α hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-α genes, IKK-α-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
patent: 5962673 (1999-10-01), Monla et al.
patent: 6268194 (2001-07-01), Karin et al.
patent: 6395545 (2002-05-01), Monla et al.
Mock, B.A., et al. CHUK3, A Conserved Helix-Loop-Helix Ubiquitous Kinase, Maps To Human Chromosome 10 And Mouse Chromosome 19. Genomics. 1995, vol. 27, pp. 348-351.
Traenckner, E.B-M.et al. Phosphorylation of Human IκB-Alpha On Serines 32 and 36 Controls IκB-Alpha Proteolysis And NF-κKB Activation in Response To Diverse Stimuli. EMBO J. 1995, vol. 14, No. 12, pp. 2876-2883.
DiDonato, J., et al. Mapping of The Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination And Degradation. Mol Cell. Biol. Apr. 1996, vol. 16, No. 4, pp. 1295-1304.
Lee, F.S, et al. Activation Of The IκB Alpha Kinase Complex By MEKK1, A Kinase Of The JNK Pathway. Cell. Jan. 24, 1997, vol. 88, pp. 213-222.
Chen et al. 1996, Cell 84:853-62.
Regnier et al., 1997 90:373-83.
Connelly et al., 1995 Cell. Mol. Biol. Res. 41:537-49.
Hillier et al., 1996 EST #AA047396 WashU-Merck EST Project.

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