Ikk.beta. regulates transcription factors

Details Ikk.beta. regulates transcription factors Ikk.beta. regulates transcription factors

1998-12-29

2000-06-20

Elliot, George C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 6, 435 71, 435 29, 435 941, 435183, 536 232, C12N 121, C12N 510, C12N 912, C12N 1554

Patent

active

06077701&

ABSTRACT:
A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compounds.

REFERENCES:
patent: 5851812 (1998-12-01), Goeddel et al.
Woronicz J.D. et al. "I(kappa) B kinase-(beta): NF-(kappa)B activation and complex formation with I(kappa)B kinase-(alpha) and NIk" Science, vol. 278 Oct. 31, 1997 pp. 866-869.
Mercurio F. et al. "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation" Science, vol. 278, Oct. 31, 1997 pp. 860-866.
Maniatis T. "Catalysis by a Multiprotein I(KAPPA)B Kinase Complex" Science, vol. 278, Oct. 31, 1997, pp. 818-819.
Nakano H. et al. "Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase--1" Proceedings of the National Academy of Sciences of the United States of America, vol 95, No. 7, Mar. 31, 1998 pp. 3537-3542.

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