IKK-.beta. proteins, nucleic acids and methods

Details IKK-.beta. proteins, nucleic acids and methods IKK-.beta. proteins, nucleic acids and methods

1997-07-10

1998-12-22

Grimes, Eric

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4352523, 435325, 536 232, C12N 121, C12N 510, C12N 912, C12N 1554

Patent

active

058518126

ABSTRACT:
The invention provides methods and compositions relating to an I.kappa.B kinase, IKK-.beta., and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-.beta. encoding nucleic acids or purified from human cells. The invention provides isolated IKK-.beta. hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-.beta. genes, IKK-.beta.-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Koyama et al., Genomics 26:245-253, 1995.
Jung et al., Cancer Res. 57:24-27, 1997.
Kumar et al., Proc. Natl. Acad. Sci. USA 91:6288-6292, 1994.
Schouten et al., EMBO J. 16:3133-3144, 1997.
McElhinny et al., Mol. Cell. Biol. 16:899-906, 1996.

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