IKK-.beta. proteins, nucleic acids and methods

Details IKK-.beta. proteins, nucleic acids and methods IKK-.beta. proteins, nucleic acids and methods

1998-06-17

1999-06-29

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435194, C12P 148

Patent

active

059167602

ABSTRACT:
The invention provides methods and compositions relating to an I.kappa.B kinase, IKK-.beta., and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-.beta. encoding nucleic acids or purified from human cells. The invention provides isolated IKK-.beta. hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-.beta. genes, IKK-.beta.-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

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Mercurio, F., et al. (1997) Science 278, 860-866.
Zandi, E., et al.(1997) Cell 91, 243-252.

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