Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-02-26
1993-06-01
Doll, John J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038835, 5303913, 5303917, 43524027, C12N 528, C07K 1528
Patent
active
052159132
ABSTRACT:
The present invention provides a human-mouse myeloma analog, designated HMMA 2.11TG/O, which has been deposited with the American Type Culture Collection (ATCC) under Accession Number HB 9583. The invention also provides a hybridoma designated F 105, which also has been deposited with the ATCC under Accession Number HB 10363.
The invention also concerns a monoclonal antibody-producing hybridoma produced by the fusion of the human-mouse myeloma analog and an antibody-producing cell. Other embodiments of the invention provide a method for producing a monoclonal antibody-producing hybridoma which comprises fusing the human-mouse myeloma analog with a human antibody-producing cell and a therapeutic method for treating a subject having a pathogen- or tumor-related disease which comprises administering to the subject a monoclonal antibody specific for the disease produced by the monoclonal antibody-producing hybridoma. In addition, a method of blocking binding of the human immunodeficiency virus and method of preventing infection of human cells by the human immunodeficiency virus are disclosed, as well as methods of detecting the virus or its antigen.
REFERENCES:
patent: 4574116 (1986-03-01), Kaplan et al.
patent: 4755457 (1988-07-01), Robert-Guroff et al.
patent: 4843011 (1989-06-01), Sarngadharan et al.
Thali, et al. "Characterization of a Discontinuous Human Immunodeficiency Virus Type 1 gp 120 Epitope Recognized by a Broadly Reactive Neutralizing Human Monoclonal Antibody."
Journal of Virology, vol. 65, No. 11, pp. 6188-6193, Nov. 1991.
McMichael, et al. (Eds.) Monoclonal Antibodies in Clinical Medicine Chapters 7 and 24. Academic Press, Inc. New York 1982.
Matsushita, et al. Human Monoclonal Antibody Directed Against an Envelope Glyco Protein of Human T-Cell Leukemia Virus . . . Proc. Natl. Acad. Sci. USA vol. 83 pp. 2672-2676 1986.
Doll John J.
Elliott George C.
Roger Williams General Hospital
White John P.
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