IGF-II analogues

Details IGF-II analogues IGF-II analogues

1995-06-05

1998-12-29

Jagannathan, Vasu S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 435243, 4352528, 435325, 4353201, 536 2351, C12N 121, C12N 510, C12N 1518, C12N 1570

Patent

active

058540253

ABSTRACT:
Insulin-like Growth Factor II (IGF-II) analogues in which at least one of R37 and R38 is replaced with another amino acid residue, the most preferred being IGF-II R37Q R38Q, can readily be produced in E. coli, unlike natural IGF-II, which is cleaved on secretion. The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they are therefore more specific in their action.

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