IGF-I fusion proteins; protection of IGF-I from degradation by h

Details IGF-I fusion proteins; protection of IGF-I from degradation by h IGF-I fusion proteins; protection of IGF-I from degradation by h

1988-07-11

1991-05-28

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 723, 43525233, 4353201, 536 27, 530303, 530350, 530351, 935 47, 935 60, 935 10, 935 13, C12N 1500, C12N 1517, C12N 1520, C12N 1570, C07K 740

Patent

active

050195000

ABSTRACT:
IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.

REFERENCES:
patent: 4571921 (1982-02-01), Itahu
patent: 4745179 (1988-05-01), Ueda et al.
Bau et al., (1913), Abst. presented at ASBC mtg., Jun. 5-9, #434.
Jansen et al., Nature 306, 609-1.
Rinauknecht et al., (1978), J.B.C. 253: 2769-2776.
Nilsson et al., (1985), Nucleic Acids Res. 13(4), 1151-1163.
Gene, (1985), vol. 35, pp. 83-89, "Expression of a Biologically Active Analogue of Somatomedin-C/Insulin-Like . . . ", M. Peters et al.
DNA, (1986), vol. 5, pp. 11-20, "A General Method for Retrieving the Components of a Genetically Engineered Fusion Protein", Paula R. Szoka et al.

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