Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-06-27
2006-06-27
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S634000, C530S399000, C530S300000, C530S303000, C530S324000
Reexamination Certificate
active
07067485
ABSTRACT:
A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to about 1.2 g/ml, and a viscosity of about 13,000 centipoise (cps) to about 19,000 cps, as measured at ambient temperature (23° C.). The IGF-I syrup is prepared by precipitating or partitioning IGF-I from solution, preferably by adjusting the solution pH or by use of a solubility enhancer to concentrate IGF-I in solution followed by removal of the solubility enhancer. The precipitated syrup is useful as a means of storing IGF-I in a stable form and as a means of preparing compositions comprising biologically active IGF-I. Pharmaceutical compositions and kits comprising this concentrated IGF-I syrup are provided. The precipitated IGF-I syrup, IGF-I reconstituted from the IGF-I syrup, pharmaceutical compositions, and kits are useful in IGF-I therapy directed to IGF-I-responsive conditions.
REFERENCES:
patent: 5324639 (1994-06-01), Brierley et al.
patent: 5410026 (1995-04-01), Chang et al.
patent: 0 297 860 (1989-01-01), None
patent: 0 440 989 (1991-08-01), None
patent: WO 96/40776 (1996-12-01), None
Johnson et al., A Month Long Effect from a Single Injection of Microencapsulated Human Growth Hormone. Nature Medicine, vol. 2, No. 7, Jul. 1996.
Johnson, et al., “A Month-Long Effect from a Single Injection of Microencapsulated Human Growth Hormone”,Nature Medicine, vol. 2, No. 7, Jul. 1996.
Hora Maninder S.
Shirley Bret A.
Chiron Corporation
Harbin Alisa A.
Kam Chih-Min
Robins Roberta L.
Suh Young J.
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