Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-05
1997-04-22
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530324, 530399, C07K 1465
Patent
active
056229321
ABSTRACT:
The instant invention provides two-chain IGF-1 superagonists which are derivatives of the naturally occurring single-chain IGF-1 having an abbreviated C domain. The invention also provides synthetic and semi-synthetic DNA sequences, recombinant DNA vectors and transformed host cells useful in the recombinant production of these analogs. The invention also provides pharmaceutical formulations comprising these IGF-1 analogs. The invention also provides methods of using these analogs in a variety of therapeutic applications. The instant invention provides IGF-1 analogs of the formula:
REFERENCES:
Humbel, European Journal of Biochemistry, 190, pp. 445-462 (1990).
DiMarchi et al, Peptides=Chemistry and Biology; Proceedings of the 12th American Peptide Symposium, Jun. 16-21, 1991 (1992) pp. 26-28, Smith and Rivier, eds.
Cascieri et al, Biochemistry 27:3229-3233 (1988).
Bayne et al, J. Biol. Chem. 249:11004-11008 (1988).
Zoler, M.L., Medical World News, 12 (1991).
DiMarchi Richard D.
Fan Li
Long Harlan B.
Boone David E.
Eli Lilly and Company
Maciak Ronald S.
Schain Howard E.
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