Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-03-24
1996-09-03
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 536 231, 536 2431, 536 2433, 435 6, C07H 2104, C07H 2102, C12Q 168
Patent
active
055525377
ABSTRACT:
Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for epsilon transcription products, and compounds which specifically bind epitopes of epsilon translation products. Novel products of the epsilon locus include the following transcription products and translation products thereof: CH4-M2", SEQ ID NO:02, residues 1-107 and, (SEQ. ID NO:06, CH4'-CH5-M1'-M2, (see SEQ ID NO:02, residues 1-72,SEQ ID NO:03 and SEQ ID NO:05) CH4'-CH5-M2'(SEQ ID NO:02, residues 1-72, SEQ ID NO:03 and SEQ ID NO:07 and CH4'-CH5-M2" (SEQ ID NO:02, residues 1-72, SEQ ID NO:03 and SEQ ID NO:06). Such epsilon products, specific probes and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment.
REFERENCES:
Hamilton and Adkinson (1992) "Measurement of total serum immunoglobulin E and allergen-specific immunoglobulin E antibody", pp. 689-701, In Rose, et al. (ed.s), Manual of Clinical Laboratory Immunology, Fourth Edition, American Society for Microbiology, Washington, D.C.
Hellman (1993) "Characterization of four novel .epsilon. chain mRNA and a comparative analysis of genes for immunoglobulin E in rodent and man", Eur. J. Immunol., 23:159-167.
Nissim et al. (1993) "Fine specificity of the IgE interaction with the low and high affinity Fc Receptor", J. Immunol., 150:1365-1374.
Peng et al. (1992) "A new isoform of human membrane-bound IgE", J. Immunol., 148(1):129-136.
Robertson et al. (1990) "Human IgE-binding Protein: A soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms", Biochemistry, 29(35):8093:8100.
Sun et al. (1991) "Transfectomas expressing both secreted and membrane-bound forms of chimeric IgE with antiviral specificity", J. Immunol., 146(1):199-205.
Zhang et al. (1992) "Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of .epsilon. heavy chain membran exons", J. Exp. Med., 176:233-243.
Zhang et al, (Feb. 1992), "Alternative splicing of exons downstream of the human IgE constant region gene yields mRNAs encoding a membrane-bound form of IgE and a large secreted form", Fed. Am. Soc. Exp. Biol. 6(4):A1153.
Zhang et al, (Mar. 6, 1992), "Epsilon mRNAs encoding novel secreted and membrane IgE results from splicing variants in IgE producing human cells", J. Allergy Clin. (Mar. 6, 1992) Immunol. 89(1 part 2) 174.
Efremov et al, (Aug. 1993), "Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals", J. Immunol. 151:2195-2207.
Seno et al, (1983), "Molecular cloning and nucleotide sequencing of human immunoglobulin e chain cDNA", Nucleic Acids Res. 11(3):719-726.
Peng et al, (1990), "Alternative mRNA splicing in the transmembrane segment of human e immunoglobulin", Fed. Am. Soc. Exp. Biol. 4(7):A1808.
Max et al, (1982), "Duplication and deletion in the human immunoglobulin e genes", Cell 29:691-699.
Flanagan et al, (1982), "The sequence of a human immunoglobulin epsilon heavy chain constant region gene and evidence for three non-allelic genes" EMBO J. 1(5):655-660.
Zhang et al, (1994), "Complex alternative RNA splicing of e-immunoglobulin transcripts produces mRNAs encoding four potential secreted protein isoforms", J. Biol. Chem. 269(1):456-462.
Max Edward E.
Saxon Andrew
Zhang Ke
Fredman Jeffrey
Jones W. Gary
Rowland Bertram I.
Sherwood Pamela J.
The Regents of the University of California
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