Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Anti-idiotypic
Reexamination Certificate
2005-08-23
2005-08-23
Saunders, David (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Anti-idiotypic
C424S158100, C424S175100, C424S810000, C435S007240, C435S007950, C435S965000, C436S822000, C436S824000, C530S387200, C530S389300, C530S389800, C530S868000
Reexamination Certificate
active
06932969
ABSTRACT:
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The invention concerns Ig fractions having reactivity to IgM, IgG F(ab′)2 or DNP hapten and no or little reactivity to non-self antigens, that is Ig fractions which have idiotypic interactions among themselves (connected fraction) or which include natural antibodies reacting with the DNP hapten. Said fractions exhibit a polyreactivity to specific autoantigens.
REFERENCES:
Berneman et al, Molecular Immunology, 30, 1499-1510, 1993.
Franek et al, Molecular Immunology, 16, 389-394, 1979.
Kimball, Introduction to Immunology, MacMillan Publishing Co. Inc., p. 10, 1983.
Dietrich et al., “A V region-connected autoreactive of normal human serum immunoglobulin G,”European Journal of Immunology22(7), pp. 1701-1706 (Jul. 1992).
Jordan et al., “Posttransplant therapy using high-does human Immunoglobulin (intravenous gammaglobulin) to control acute humoral rejection in renal and cardiac allograft recipients and potential mechanism of action,”Transplantation66(6), pp. 800-805 (Sep. 1998).
Pacheco-Garcia et al “Altered pattern of connectivity in serum immunoglubulins from pemphigus vulgaris patients,”Scandinavian Journal of Immunology49(4), pp. 424-430 (Apr. 1999).
Flan, B. “Fractionation technique and biochemical properties of IV Ig! Technique de Fractionnement et Properties Biochimiques des Immunoglobulines Intraveineuses (IGIV),”Sang Thrombose Vaisseaux11/Spec. Iss. (45-51), (Oct. 1999).
Bourel Dominique
Bruley-Rosset Martine
Dhainaut Frédéric
Lirochon Jacky
Foley & Lardner LLP
Laboratoire Francais du Fractionnement et des Biotechnologies
Saunders David
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