Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Reexamination Certificate
2005-02-08
2005-02-08
Landsman, Robert (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
C530S351000, C514S012200, C215S014000, C215S049000
Reexamination Certificate
active
06852314
ABSTRACT:
Interferon-β liquid formulations stabilized with a polyol, a non-reducing sugar or an amino acid. In particular, the formulations are stabilized with a polyol, such as mannitol. The formulations, preferably, furthermore comprise a buffer, such as acetate buffer, at a pH comprised between 3.0 and 4.0 and human albumin at a minimum quantity. The interferon-β is preferably recombinant.
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patent: 4724232 (1988-02-01), Rideout et al.
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patent: 89245 (1983-08-01), None
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Dialog Information Services, file 351, WPIL, Dialog accession no. 003925794, WPI accession no. 84-071338/12, Toray Ind Inc: “Stabilising beta-interferon having no sugar chain by adding polyol, e.g. ethylene glycol, glycerine or sugar, esp. oligo saccharide”, JP 59025333, A, 840209, 8412 (Basic) Feb. 9, 1986.
Natale Patrizia
Samaritani Fabrizio
Applied Research Systems ARS Holding N.V.
Dickstein Shapiro Morin & Oshinsky LLP.
Landsman Robert
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