IFN-β liquid formulations

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

Reexamination Certificate

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Details

C530S351000, C514S012200, C215S014000, C215S049000

Reexamination Certificate

active

06852314

ABSTRACT:
Interferon-β liquid formulations stabilized with a polyol, a non-reducing sugar or an amino acid. In particular, the formulations are stabilized with a polyol, such as mannitol. The formulations, preferably, furthermore comprise a buffer, such as acetate buffer, at a pH comprised between 3.0 and 4.0 and human albumin at a minimum quantity. The interferon-β is preferably recombinant.

REFERENCES:
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patent: 4647454 (1987-03-01), Cymbalista et al.
patent: 4724232 (1988-02-01), Rideout et al.
patent: 5004605 (1991-04-01), Hershenson et al.
patent: 5183746 (1993-02-01), Shaked et al.
patent: 5643566 (1997-07-01), Hanisch et al.
patent: 89245 (1983-08-01), None
patent: 270799 (1988-06-01), None
patent: 8902750 (1989-04-01), None
patent: 8904177 (1989-05-01), None
Dialog Information Services, file 351, WPIL, Dialog accession no. 003925794, WPI accession no. 84-071338/12, Toray Ind Inc: “Stabilising beta-interferon having no sugar chain by adding polyol, e.g. ethylene glycol, glycerine or sugar, esp. oligo saccharide”, JP 59025333, A, 840209, 8412 (Basic) Feb. 9, 1986.

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