Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-05-30
1993-06-01
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530351, 530413, 530416, 530834, C07K 302, C07K 320, C07K 1506
Patent
active
052161285
ABSTRACT:
Human natural IFN-.beta.2/IL-6 receptor and its soluble extracellular fragment are provided in substantially purified form and are shown to stimulate and to enhance beneficial effects of IFN-.beta.2/IL-6, such as its antiproliferative activity. Polyclonal and monoclonal antibodies raised against the soluble fragment of the receptor are also provided.
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Yamasaki, K. et al. "Cloning and Expression of the Human Interleukin-6 (BSF-2/IFN.beta. 2) Receptor", Science, vol. 241, Reports, 2 Aug. 1988, pp. 825-828.
Novick, D. et al. "Soluble Cytokine Receptors Are Present In Norman Human Urine", J. Exp. Med., vol. 170, Oct. 1989, pp. 1409-1414.
Novick, D. et al. "Monoclonal Antibodies for Affinity Purification of IL-6/IFN-.beta..sub.2 and for Neutralization of HGF Activity", Hybridoma, vol. 8, No. 5, 1989, pp. 561-567.
Revel, M. et al. "Biological Activities of Recombinant Human IFN-.beta.2/IL-6 (E. coli)", Ann. N.Y. Acad. Sci., vol. 557, Jun. 15, 1989, pp. 144-156.
Taga, T. et al. "Interleukin-6 Triggers the Association of Its Receptor with a Possible Signal Transducer, bp130", Cell, vol. 58, 573-581, Aug. 11, 1989.
Chen Louise
Engelmann Hartmut
Novick Daniela
Revel Michel
Rubinstein Menachem
Russel Jeffrey E.
Yeda Research and Development Co. Ltd.
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