Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1987-12-23
1990-03-20
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 7, 4351722, 435235, 435948, 436548, 530387, 530808, 530809, 530826, C12Q 170, C12N 1500, G01N 3353
Patent
active
049101315
ABSTRACT:
The invention describes a new process for the production of anti-viral diagnostics, as well as an example of one antibody useful in detecting a wide variety of pathogenically important alphaviruses. The process includes, but is not limited to, the isolation of monoclonal antibodies directed against internal viral components. Such antibodies may be generated by conventional immunization in vivo or in vitro using subviral particles or synthetic peptides corresponding to specific viral proteins. Alternatively, synthetic peptides derived from the cytoplasmic domains of envelope proteins may be used to elicit monoclonal idiotypic and anti-idiotypic antibodies following immunization in vitro and/or in vivo.
The anti-alphavirus antibody included in the invention is an example of the type of reagent produced. It was produced as an anti-idiotype against monoclonal antibodies to a synthetic peptide derived from Semliki Forest virus. The monoclonal anti-idiotype is specific for the genome-containing nucleocapsid structure not only of Semliki Forest virus, but of every alphavirus tested thus far.
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This invention was made with the assistance of Grant Nos. GM-29765, GM-33904, and AI-18599 from the National Institute of Health. The Government has certain rights in the invention.
Helenius Ari H.
Mellman Ira S.
Vaux David
Graeter Janelle
Warden Robert J.
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