IdeS, an IgG-degrading enzyme of Streptococcus pyogenes

Details IdeS, an IgG-degrading enzyme of Streptococcus pyogenes IdeS, an IgG-degrading enzyme of Streptococcus pyogenes

2002-12-17

2010-02-23

Mondesi, Robert B (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S069100, C435S069700, C435S253400, C435S320100, C536S023700, C530S350000

Reexamination Certificate

active

07666582

ABSTRACT:
A polypeptide isolated fromS. pyogenesis described, having IgG cysteine protease activity. The protease is designated IdeS, Immunoglobulin G-degrading enzyme ofS. pyogenes. A polypeptide comprises SEQ ID NO: 1 and variants and fragments thereof having IgG cysteine protease activity or the ability to generate an immune response againstS. pyogenesin an individual. Polynucleotides encoding these polypeptides and the polypeptides may be used in generating an immune response in an individual. IdeS protease inhibitors may be used in the treatment ofS. pyogenesinfection.

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Accession No. Q9F1R7, Mar. 1, 2001.

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