Identifying patients at risk for life threatening arrhythmias

Details Identifying patients at risk for life threatening arrhythmias Identifying patients at risk for life threatening arrhythmias

2005-06-21

2009-10-27

Marcheschi, Michael A (Department: 1797)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C800S281000, C800S281000

Reexamination Certificate

active

07608458

ABSTRACT:
The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.

REFERENCES:
patent: 5018067 (1991-05-01), Mohlenbrock
patent: 5437285 (1995-08-01), Verrier
patent: 6099469 (2000-08-01), Armstrong
patent: 6210976 (2001-04-01), Sabbadini
patent: 6274332 (2001-08-01), Keating
patent: 6306087 (2001-10-01), Barnhill
patent: 6368823 (2002-04-01), Bril
patent: 6432644 (2002-08-01), Keating
patent: 6458542 (2002-10-01), George, Jr. et al.
patent: 6500630 (2002-12-01), Conover et al.
patent: 6571129 (2003-05-01), Schaldach
patent: 6597952 (2003-07-01), Mika
patent: 6647341 (2003-11-01), Golub
patent: 7208273 (2007-04-01), Keating
patent: 2002/0049772 (2002-04-01), Rienhoff, Jr.
patent: 2002/0059030 (2002-05-01), Otworth
patent: 2002/0076809 (2002-06-01), Steinmeyer et al.
patent: 2002/0077470 (2002-06-01), Walker
patent: 2002/0086297 (2002-07-01), Siffert
patent: 2002/0115073 (2002-08-01), Papadopoulos
patent: 2002/0155539 (2002-10-01), Ruben et al.
patent: 2002/0165161 (2002-11-01), Allison
patent: 2002/0182599 (2002-12-01), Fishman
patent: 2003/0004402 (2003-01-01), Hitt
patent: 2003/0096782 (2003-05-01), Bristow
patent: 2003/0108924 (2003-06-01), George, Jr. et al.
patent: 2003/0162192 (2003-08-01), Sotos
patent: 2003/0175795 (2003-09-01), Walker
patent: 2003/0198970 (2003-10-01), Roberts
patent: 2003/0228565 (2003-12-01), Oestreicher
patent: 2003/0235838 (2003-12-01), Keating
patent: 0721786 (1996-07-01), None
patent: 0842475 (1997-02-01), None
patent: 1100825 (2000-02-01), None
patent: 1176197 (2002-01-01), None
patent: 95/15116 (1995-06-01), None
patent: 96/28537 (1996-09-01), None
patent: 98/09226 (1998-03-01), None
patent: 99/27140 (1999-06-01), None
patent: 99/51778 (1999-10-01), None
patent: 99/67628 (1999-12-01), None
patent: 01/81895 (2001-11-01), None
patent: 01/92567 (2001-12-01), None
patent: 02/052033 (2002-07-01), None
patent: 02/086447 (2002-10-01), None
patent: WO 03/002757 (2003-01-01), None
patent: WO 03/006687 (2003-01-01), None
patent: 03/040407 (2003-05-01), None
patent: WO 2004/005931 (2004-01-01), None
Ken Rubenstein, Ph.D., Post-Genomic Biomarkers: Revolutionizing Drug Development and Diagnostics, Report #9129, Sep. 2003, D&MD Publications.
D. Kent Arrell, et al., Cardiovascular Proteomics, Evolution and Potential, Circ. Res. 2001; 88:pp. 763-773.
Urban A. Kiernan, Comparative Urine Protein Phenotyping Using Mass Spectrometric Immunoassay, Journal of Proteome Research.( 2003 ).
Eleftherios P. Diamandis, Proteomic Patterns in Biological Fluids: Do They Represent the Future of Cancer Diagnostics?, Clinical Chemistry 49:8, pp. 1272-1278. (2003).
Emanuel F. Petricoin, III, et al., Use of Proteomic Patterns in Serum to Identify Ovarian Cancer, The Lancet, vol. 359, Feb. 16, 2002, pp. 572-577.
Urban A. Kiernan, Comparative Urine Protein Phenotyping Using Mass Spectrometric Immunoassay, Journal of Proteome Research.
Eleftherios P. Diamandis, Proteomic Patterns in Biological Fluids: Do They Represent the Future of Cancer Diagnostics?, Clinical Chemistry 49:8, pp. 1272-1278.
Fananapazir, et al., Genotype-Phenotype Correlations in Hypertrophic Cardiomyopathy: Insights Provided by Comparisons of Kindreds with Distinct and Identical Beta-myosin Heavy Chain Gene Mutations, Circulation, 1994; 89 (1): 22-32.
Samani, et al., A Meta-analysis of the Association of the Deletion Allele of the Angiotensin-Converting Enzyme Gene with Myocardial Infarction, Circulation, 1996; 94: 708-12.
Aronsky, et al., An Integrated Decision Support System for Diagnosing and Managing Patients with Community-Acquired Pneumonia, Proc. AMIA Symp., 1999; 197-201.
Colombet, et al., Decision Aids for Triage of Patients with Chest Pain: A Systematic Review of Field Evaluation Studies, Proc. AMIA Symp., 1999; 231-35.
Jouven, et al., Predicting Sudden Death in the Population: The Paris Prospective Study I, Circulation, 1999; 99: 1978-83.
Dunn, Studying Heart Disease Using the Proteomic Approach, Drug Discovery Today, Feb. 1, 2000; 5(2): 76-84.
Jouven et al., Circulating Nonesterified Fatty Acid Level as a Predictive Risk Factor for Sudden Death in the Population, Circulation, 2001; 101: 756-61.
Iwasa, et al., Multiple Single-Nucleotide Polymorphisms (SNPS) in the Japanese Population in Six Candidate Genes for Long QT Syndrome, J. Hum. Genet., 2001; 46: 158-62.
Christodoulides, et al., A Microchip-Based Multianalyte Assay System for the Assessment of Cardiac Risk, Analytical Chemistry, 2002; 74(13): 3030-36.
Moss, et al., Increased Risk of Arrhythmic Events in Long-QT Syndrome with Mutations in the Pore Region of the Human Ether-a-go-go-Related Gene Potassium Channel, Circulation, 2002; 105: 794-99.
Iwasa, et al., Twenty Single-nucleotide Polymorphisms in Four Genes Encoding Cardiac Ion Channels, J. Hum. Genet., 2002; 47(4): 208-12.
Hirschhorn, et al., a Comprehensive Review of Genetic Association Studies, Genetics in Medicine, 2002; 4(2): 45-61.
Frank-Hansen, et al., Mutations in the Genes KCND2 and KCND3 Encoding the Ion-Channels Conducting the Cardiac Transient Outward Current (ITO) is not a Frequent Cause of Long QT Syndrome, Am. J. Hum. Genet., 2002; 71(4 Supp.): 521.
Issaq, et al., the SELDI-TOF MS Approach to Proteomics: Protein Profiling and Biomarker Identification, Biochemical and Biophysical Research Communications, Apr. 5, 2002; 292(3): 587-92.
Hegele, SNP Judgments and Freedom of Association, Arteriosclerosis, Thrombosis, and Vascular Biology, 2002; 22: 1058-61.
Splawski, et al., Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia, Science, Aug. 23, 2002, 297:1333-36.
Danne, et al., Prognostic Implications of Elevated Whole Blood Choline Levels in Acute Coronary Syndromes, The Am. J. Cardiology, May 1, 2003; 91(9): 1060-67.
Dhar et al., Prognostic significance of metastatic lymph node size in patients with gastric cancer, British J. of Surgery, 2003; 90: 1522-30.
Kuzuya et al., Report of the Committee on the classification and diagnostic criteria of diabetes mellitus, Diabetes Res. and Clin. Practice, 2002; 55: 65-85.

Affiliated with

Also associated with

Rating

Identifying patients at risk for life threatening arrhythmias does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identifying patients at risk for life threatening arrhythmias, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identifying patients at risk for life threatening arrhythmias will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4072646