Identifying and characterizing genes

Details Identifying and characterizing genes Identifying and characterizing genes

2008-05-13

2008-05-13

Chen, Shin-Lin (Department: 1632)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S320100, C435S455000, C424S093210

Reexamination Certificate

active

10112503

ABSTRACT:
The invention provides methods and materials for identifying and characterizing genes related to phenotypes such as cancer and cell survivability. Also provided in the invention are cells and transgenic, non-human mammals that can be used in these methods.

REFERENCES:
patent: 5919997 (1999-07-01), Beach et al.
patent: 6639121 (2003-10-01), DePinho et al.
patent: WO 97/20463 (1997-06-01), None
Oberg et al (2004) Loss of mismatch of MHC Class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo-role of KARAP/DAP12-dependent and independent pathways. Eur. J. Immunol. 34:1646-1653.
Walther et al. (1996) Cell Type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting. J. Mol Med. 74:379-392.
Kolb et al. (1999) Insertion of a foriegn gene into the beta-casein locus by Cre-mediated site-specific recombination. Gene 227:21-31.
Houdebine. (2000) Transgenic animal bioreactors. Transgenic Research. 9:305-320.
Houdebine, L-M., 2002 (Journal of Biotechnology, vol. 98, p. 145-160).
Leiter et al. (2002) Diabetologia 45:296-308.
Efrat et al., 1995, PNAS, vol. 92, pp. 3576-3580.
Allen, et al., “Complementation tagging of cooperating oncogenes in knockout mice”, Cancer Bio., 7:299-306 (1996).
Berns, et al., “Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice”, Cancer Res., 59:1773s-1777s (1999).
Bedigan et al., “Spontaneous and Induced Leukemias of Myeloid Origin in Recombinant Inbred BXH Mice,”J. Virol., 1984, 51(3):586-594.
Chin et al., “Cooperative effects ofINK4aandrasin melanoma susceptibility in vivo,”Genes Dev., 1997, 11:2822-2834.
Chin et al., “Essential role for oncogenic Ras in tumour maintenance,”Nature, 1999, 400:462-472.
Clark et al., “Genomic analylsis of metastasis reveals an essential role for RhoC,”Nature, 2000, 406:532-535.
Duggan et al., “Expression profiling using cDNA microarrays,”Nature Genetics Suppl., 1999, 21:10-14.
Fisher et al., “Development of a flexible and specific gene delivery system for production of murine tumor models,”Oncogene, 1999, 18(38):5253-5260.
Ganss et al., “A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice,”EMBO J., 1994, 13(13):3083-3093.
Gilbert et al., “Susceptibility of AKXD Recombinant Inbred Mouse Strains to Lymphomas,”J. Virol., 1993, 67(4):2082-2090.
Hahn et al., “Creation of human tumour cells with defined genetic elements,”Nature, 1999, 400:464-468.
Haupt et al., “Novel Zinc Finger Gene Inplicated asmycCollaborator by Retrovirally Accelerated Lymphomagenesis in Eμ-mycTransgenic Mice,”Cell, 1991, 65:753-763.
Herlyn,Molecular and Cellular Biology of Melanoma, 1993, R. G. Landes Company, Austin (Table of Contents only).
Kistner et al., “Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice,”Proc. Natl. Acad. Sci. USA, 1996, 93:10933-10938.
Malumbres and Pellicer, “Ras Pathways to Cell Cycle Control and Cell Transformation,”Frontiers in Bioscience, 1998, vol. 3, 49 pgs.
Nesbit et al., “Basic fribroblast growth factor induces a transformed phenotype in normal human melnocytes,”Oncogene, 1999, 18(47):6469-6476.
Paddison et al., “Stable suppression of gene expression by RNAi in mammalian cells,”Proc. Natl. Acad. Sci. USA, 2002, 99(3):1443-1448.
Pierucci et al., “NGF-withdrawal induces apoptosis in pancreatic beta cells in vito,”Diabetologia, 2001, 44:1281-1295.
Rigel et al., “Lifetime risk for development of skin cancer in the U.S. population: Current estimate is now 1 in 5,”J. Am. Acad. Dermatol., 1996, 35(6):1012-1013.
Shimizu et al., “High Expression of Macrophage Migration Inhibitory Factor in Human Melanoma Cells and Its Role in Tumor Cell Growth and Angiogenesis,”Biochem. Biphys. Res. Comm., 1999, 264:751-758.
Shirasawa et al., “Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activate Ki-ras,” Science, 260:85-88.
Skobe et al., “Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis,”Nature Medicine, 2001, 7(2):192-198.
Thomson et al., “Differentiation Antigens of Melanocytes and Melanoma: Analysis of Melanosome and Cell Surface Markers of Human Pigmented Cells With Monoclonal Antibodies,”J. Invest. Dermatol., 1988, 90:459-466.
Tobin et al., “Consequences of altered TGF-β expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects,”Oncogene, 2002, 21:108-118.
Tokunaga et al., “Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line,”Br. J. Cancer, 2000, 83(6):833-839.
van Lohuizen et al., “Identification of Cooperating Oncogenes in Eμ-mycTransgenic Mice by Provirus Tagging,”Cell, 1991, 65:737-752.
Velculescu, “Tantalizing Transcriptions—SAGE and Its Use in Global Gene Expression Analysis,”Science, 1999, 286:1491-1492.
ClonTech Laboratories Inc., “Tet-Inducible Retroviral cDNA Library User Manual,” PT3352-1 (PR13438), Catalog # HL8500BC, published Mar. 16, 2001, pp. 1-23.
Lewandoski, M., “Conditional Control of Gene Expression in the Mouse,” Nature Reviews, 2:743-755 (2001).
Valentis Home page, Geneswitch Systems Press Releases. Apr. 12, 2005. <http://www.geneswitch.com/press/index.html>.
Indra et al., “Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases,” Nucleic Acids Research, 27:4324-4327 (1999).
“Mouse genetics and transgenics,” A Practical Approach Series Book, Jackson & Abbott (edtrs); Oxford university Press (2000), p. 218 (9.1.2) and 220 (9.1.4).
“Manipulating the Mouse Embryo”, Hogan, Beddington, Costantini & Lacy (2nd Ed.); CSHL Press (1994), p. 293 paragraphs 1 & 2.
“Manipulating the Mouse embryo”, Nagy, Gertsenstein, Vintersten and Behringer (3rd Ed.); CSHL Press (2003), p. 511 and 515.
Moody et al., “Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis,” Cancer Cell, 2:451-461 (2002).
Huettner et al., “Reversibility of acute B-cell leukaemia induced by BCR-ABL1,” Nature Genetics, 24:57-60 (2000).
Fisher et al., “Induction and apoptosis regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes,” Genes & Development, 15:3249-3262 (2001).
Ji et al., “The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies,” Cancer Cell, 9:485-495 (2006).
Chin et al., “Essential role for oncogenic Ras in tumor maintenance,” Nature, 400: 468-472 (1999).

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