Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2004-07-23
2011-10-18
Ware, Debbie K (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C424S405000, C435S004000, C435S007200, C435S007800, C435S007210, C435S007320, C435S832000, C435S962000, C435S967000, C435S970000
Reexamination Certificate
active
08039229
ABSTRACT:
The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant toBacillus thuringiensisCry toxins have measurably altered alkaline phosphatase (ALP) activity as compared to insects that are susceptible to Cry toxins. This and other surprising discoveries reported herein have broad implications in areas such as managing and monitoring the development of insect resistance to B.t. toxins. For example, the subject invention provides a simple and fast assay (enzymatic or otherwise) for detecting ALP activity levels and thereby monitoring the development of resistance by insects to crystal protein insect toxins. There was no prior motivation or suggestion to go about resistance monitoring using this simple and easy approach.
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Adang Michael J.
Fuentes Juan Luis Jurat
McNall Rebecca
Baker & Daniels LLP
University of Georgia Research Foundation Inc.
Ware Debbie K
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