Identification of thymically derived CD4 T cells by protein...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007240

Reexamination Certificate

active

07960125

ABSTRACT:
The invention provides methods of identifying naïve T cells by expression of PTK7.

REFERENCES:
Boursalian; et al., “Continued maturation of thymic emigrants in the periphery”, Nature Immunology, Apr. 2004, 5 (4):418-25.
Chen; et al., “Impaired Allogeneic Activation and T-helper I Differentiation of Human Cord Blood Naive CD4 T Cells”, Biology of Blood and Marrow Transplantation (2006), 12:160-171.
Hazenberg; et al., “Thymic output: a bad TREC record”, Nature Immunology, Feb. 2003, 4(2):97-99.
Juliien; et al., “Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation”, International Immunology (2003), 15(12):1461-1472.
Lu; et al., “PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates”, Nature, Jul. 2004, 430:93-98.
McFarland; et al., “Identification of a human recent thymic emigrant phenotype”, PNAS, Apr. 11, 2000, 97 (8):4215-4220.
Nanoyama; et al., “Diminished Expression of CD40 Ligand by Activated Neonatal T Cells”, J. Clin. Invest., Jan. 1995, 95:66-75.

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