Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1997-03-21
2000-11-14
Yucel, Remy
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4352542, 4353201, 435325, 435348, 435419, 536 235, 536 251, C07H 2100, C12N 510, C12N 1512, C12N 1563
Patent
active
061468770
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a Progression Elevated Gene-3 protein. This invention also provides isolated nucleic acid molecule encoding a human Progression Elevated Gene-3 protein. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically recognizing a nucleic acid molecule encoding a Progression Elevated Gene-3 protein. This invention provides a method of detecting expression of the Progression Elevated Gene-3 in a sample. This invention provides an isolated nucleic acid molecule encoding a Progression Elevated Gene-3 protein operatively linked to a regulatory element. This invention provides a host vector system for the production of a polypeptide having the biological activity of a Progression Elevated Gene-3 protein. This invention also provides a purified Progression Elevated Gene-3 protein and a fragment thereof. This invention provides an antibody capable of specifically binding to a Progression Elevated Gene-3 protein. This invention provides a method for determining whether cells are in progression. This invention provides a method for diagnosing the aggressiveness of cancer cells by measuring the expression of Progression Elevated Gene-3. Finally, this invention provides various uses of the Progression Elevated Gene-3, its protein and the antibody against its protein.
REFERENCES:
Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Orkin and Motulsky, co-chairs. National Institues of Health, Dec. 7, 1995.
Crystal. Transfer of genes to humans: Early lessons and obstacles to success. Science 270: 404-410, Oct. 1995.
Stull et al., Antigene, ribozyme and aptamer nucleic acid drugs: Progress and prospects. Pharm. Res. 12:465-483, Apr. 1995.
Babiss, P. B., et al. (1985) "Reversibility of Progression of the Transformed Phenotype in Ad5-Transformed Rat Embryo Cells," Science 228:1099-1101.
Fisher, P. B. (1984) in Tumor Promotion and Cocarcinogenesis In Vitro, Mechanisms of Tumor Promotion, ed. Slaga, T. J. (CRC Press, Boca Raton, FL), pp. 57-123.
Fisher, P. B., et al. (1979) "Tumor Promoters and Epidermal Growth Factor Stimulate Anchorage--Independent Growth of Adeovirus-Transformed Rat Embryo Cells," Cell 18:695-705.
Fisher, P. B., et al. (1979) "Tumour Promoters Enhance Anchorage--Independent Growth of Adenovirus-transformed Cells Without Altering the Integration Pattern of Viral Sequences," Nature 281:591-594.
Fisher, P. B., et al. (1979) "Phenotypic Properties and Tumor Promoter-induced Alterations in Rat Embryo Cells Transformed by Adenovirus," Cancer Res. 39:3051-3057.
He, B., et al. (1996) "The Carboxyl Terminus of the Murine MyD116 Gene Substitutes for the Corresponding Domain of the .gamma..sub.1 34.5 Gene of Herpes Simplex Virus To Preclude the Premature Shutoff of Total Protein Synthesis in Infected Human Cells," J. Virol. 70:84-90.
Jiang, H. and P. Fisher (1993) "Use of a Sensitive and Efficient Subtraction Hybridization Protocol for the Identification of Genes Differentially Regulated During the Induction of Differentiation in Human Melanoma Cells." Mol Cell Different. 1:285-299.
Reddy, P. G., et al. (1993) "Identification and Cloning of Genes.sub.- Involved in Progression of Transformed Phenotype," in Chromosome and Genetic Analysis, Methods in Molecular Genetics, ed. Adolph, K. W. (Academic, Orlando FL), vol. 1, pp. 68-102.
Shen, R., et al. (1995) "Identification of the Human Prostatic Carcinoma Oncogene PTI-1 by Rapid Expression Cloning and Differential RNA Display," PNAS USA 92: 6778-6782.
Su, Z.-Z., et al. (1996) "Surface-epitope Masking and Expression Cloning Identifies the Human Prostate Carcinoma Tumor Antigen Gene PCTA-1 a Member of the Galectin Gene Family," PNAS USA 93:7252-7257.
Su, Z.-z., et al. (1993) "Defining the Critical Gene Expression Changes Associated with Expression and Suppression of the Tumorigenic and Metastic Phenotype in the Ha-ras-Transformed Cloned Rat Embryo Fibroblast Cells," Oncogene 8:1211-1219.
Su, Z.-z., et al. (1991) "Suppression of Adenovirus Type 5 E1A-Mediated Transformation and Expression of the Transformed Phenotype by Caffeic Acid Phenethyl Ester (CAPE)," Mol. Carcinog 4:231-242.
Su, Z-z., et al. (1991) "Induction of Transformation Progression in Type 5 Adenovirus-transformed Ray Embryo Cells by a Cloned Protein Kinase C .beta..sub.1 Gene and Reversal of Progression by 5-azacytidine," Oncogene 9:1123-1132.
Zhan, Q., et al. (1994) The gadd and MyD Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth, Mol. Cell. Biol. 14:2361-2371.
Larson Thomas G.
The Trustees of Columbia University in the City of New York
White John P.
Yucel Remy
LandOfFree
Identification of the progression elevated gene-3 and uses there does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification of the progression elevated gene-3 and uses there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of the progression elevated gene-3 and uses there will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2063938