Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Reexamination Certificate
2005-02-15
2005-02-15
Housel, James (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
C424S184100, C424S185100, C424S191100, C514S002600, C530S300000, C530S350000
Reexamination Certificate
active
06855323
ABSTRACT:
The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
REFERENCES:
patent: 5817644 (1998-10-01), Gustafson
patent: WO9640766 (1996-12-01), None
NCBI printout of Genbank Accession No. L42636.*
Sequence Comparisons, us-10-097-013-2.rag, pp. 10-12 (Result 5), us-10-087-013-2_copy_1279_1554.rag, pp. 3 and 6 (Results 4, 9, and 10).*
NCBI printout of Genbank Accession No. AF134154.*
NCBI printout of Genbank Accession No. AAD29126.*
Buffet et al.,Plasmodium falciparumdomain mediating adhesion to chondroitin sulfate A: A receptor for human placemental infection, PNAS 96: 12743 (Oct. 1999).
Scherf, A., FCR3 CSA ligand [Plasmodium falciparum], GenBank accession No. AJ133811 (Apr. 23, 1999).
Costa et al., Immunization with recombinant duffy-binding-like γ3 Induces pan-reactive and adhesion-blocking antibodies against placental chondroitin sulfate A-bindingplasmodium falciparumparasites, JID 188: 153 (2003).
Gamain et al., Identification of a 67-amino acid region of theplasmodium falciparumvariant surface antigen that binds chondroitin sulfate A and elicits antibodies reactive with the surface of placental isolates, in press.
Baruch, D. I., et al. (1995) Cloning theP. falciparumGene Encoding PfEMP1, a Malarial Variant Antigen and Adherence Receptor on the Surface of Parasitized Human Erythrocytes. Cell 82:77-87.
Baruch, D. I., et al. (1996)Plasmodium falciparumErythrocyte Membrane Protein 1 is a Parasitized Erythrocyte Receptor for Adherence to CD36, Thrombospondin, and Intercellular Adhesion Molecule 1. Proc. Natl. Acad. Sci. 93:3497-3502.
Baruch, D. I., et al. (1997) Identification of a Region of PfEMP1 That Mediates Adherence ofPlasmodium falciparumInfected Erythrocytes to CD36: Conserved Function With Variant Sequence. Blood 90(9):3766-3775.
Berendt, A. R., et al. (1989) Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor forPlasmodium falciparum.Nature 341:57-59.
Bevilacqua, M. P. et al. (1989) Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins. Science 243:1160-1165.
Buffet, P. A., et al. (1999)Plasmodium falciparumdomain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection. Proc. Natl. Acad. Sci. 96(22):12743-12748.
Buffet, P. A. et al., (1999)Plasmodium falciparumdomain mediating adhesion to chondroitin sulfate A: a receptor for human placental infection. Database EMBL PFA133811, Accesion No. AJ133811.
Chen, Q., et al. (1998) Identification ofPlasmodium falciparumErythrocyte Membrane Protein 1 (PfEMP1) as the Rosetting Ligand of the Malaria ParasiteP. falciparum.J. Exp. Med. 187:15-23.
Fried, M., et al. (1996) Adherence ofPlasmodium falciparumto Chondroitin Sulfate A in the Human Placenta. Science 272:1502-1504.
Fried, M., et al. (1998) Maternal antibodies block malaria. Nature 395:851-852.
Gysin, J., et al. (1997) Chondroitin sulfate of thrombomodulin is an adhesion receptor forPlasmodium falciparum-infected erythrocytes. Mol. Biochem. Parasitol. 88:267-271.
Hernandez-Rivas, R., et al. (1997) ExpressedvarGenes Are Found inPlasmodium falciparumSubtelomeric Regions. Mol. Cell. Biol. 17(2):604-611.
Miller, L. H., et al. (1998) Motherhood and malaria. Nature Medicine 4(11):1244-1245.
Osborn, L., et al. (1989) Direct Expression Cloning of Vascular Cell Adhesion Molecule 1, a Cytokine-Induced Endothelial Protein That Binds to Lymphocytes. Cell 59:1203-1211.
Pasvol, G., et al. (1978) Separation of viable schizont-infected red cells ofPlasmodium falciparumfrom human blood. Ann. Trop. Med. Parasitol. 72(1):87-88.
Pouvelle, B., et al. (1998)Plasmodium falciparumet chondroitine-4-sulfate: le nouveau couple cle de la sequestration. Med. Trop. 58:187-198.
Reeder, J. C., et al. (1999) The adhesion ofPlasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated byP. falciparumerythrocyte membrane protein 1. Proc. Natl. Acad. Sci. 96:5198-5202.
Robert, C., et al. (1995) Chondroitin-4-sulphate (proteoglycan), a receptor forPlasmodium falciparum-infected erythrocyte adherence on brain microvascular endothelial cells. Res. Immunol. 146:383-393.
Rogerson, S. J., et al. (1995) Chondroitin Sulphate A Is a Cell Surface Receptor forPlasmodium falciparum-infected Erythrocytes. J. Exp. Med. 182:15-20.
Rowe, J. A., et al. (1997)P. falciparumrosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 388:292-295.
Scherf, A. (1998) Antigenic variation in malaria:in situswitching, relaxed and mutually exclusive transcription of var genes during intra-erythorcytic development inPlasmodium falciparum. Database EMBL PFA7940, Accesion No. AJ007940.
Scherf, A., et al. (1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development inPlasmodium falciparum. EMBO J. 17(18):5418-5426.
Shinohara, Y., et al. (1995) Use of a Biosensor Based on Surface Plasmon Resonance and Biotinyl Glycans for Analysis of Sugar Binding Specificities of Lectins. J. Biochem. 117:1076-1082.
Simmons, D., et al. (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331:624-627.
Smith, J. D., et al. (1995) Switches in Expression ofPlasmodium falciparum varGenes Correlate with Changes in Antigenic and Cytoadherent Phenotypes of Infected Erythrocytes. Cell 82:101-110.
Smith, J. D., et al. (1998) Analysis of adhesive domains from the A4VARPlasmodium falciparumerythrocyte membrane protein-1 indentifies a CD36 binding domain. Mol. Biochem. Parasitol. 97:133-148.
Steketee, R. W., et al. (1996) The Problem of Malaria and Malaria Control in Pregnancy in Sub-Saharan Africa. Am. J. Trop. Med. Hyg. 55(1):2-7.
Su, X. Z., et al. (1995) The Large Diverse Gene Family var Encodes Proteins Involved in Cytoadherence and Antigenic Variation ofPlasmodium falciparum-Infected Erythrocytes. Cell 82:89-100.
Vicart, P., et al. (1993) Cell Adhesion Markers Are Expressed by a Stable Human Endothelial Cell Line Transformed by the SV40 Large T Antigen Under Vimentin Promoter Control. J. Cell Physiol. 157:41-51.
Wiesner, J., et al. (1998) Biology of Giant Proteins of Plasmodium: Resolution on Polyacrylamide-Agarose Composite Gels. Parasitol. Today 14(1):38-40.
Baruch Dror I.
Buffet Pierre
Fujii Nobutaka
Gamain Benoit
Gysin Jurg
Housel James
Knobbe Martens Olson & Bear LLP
Lucas Zachariah
The United States of America as represented by the Department of
LandOfFree
Identification of the domain of Plasmodium falciparum... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification of the domain of Plasmodium falciparum..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of the domain of Plasmodium falciparum... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3462980