Identification of self and non-self antigens implicated in...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C424S185100

Reexamination Certificate

active

07084247

ABSTRACT:
The present invention provides isolated peptides relating to the autoimmune disease pemphigus vulgaris. The peptides relating to pemphigus vulgaris are self epitopes derived from human pathogens which are implicated in the aetiology and remissions of the disease. Pharmaceutical preparations for tolerizing and/or immunizing individuals are provided as well as methods relating thereto. Methods are provided for identifying other self and non-self epitopes involved in human autoimmune disease and similar pharmaceutical preparations and methods of use for these epitopes are also provided.

REFERENCES:
patent: 5130297 (1992-07-01), Sharma et al.
patent: 5194425 (1993-03-01), Sharma et al.
patent: 5874531 (1999-02-01), Strominger et al.
patent: WO 90/08161 (1990-07-01), None
patent: WO 92/16234 (1992-10-01), None
patent: WO 92/18150 (1992-10-01), None
patent: WO 93/10813 (1993-06-01), None
patent: WO 94/05303 (1994-03-01), None
patent: WO 94/06828 (1994-03-01), None
patent: WO 95/12313 (1995-05-01), None
Veldman et al., “T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals” Journal of Immunology, 2004, 172:3883-3892.
Goon et al., “Pemphigus vulgaris following varicella infection” Clinical and Experimental Dermatology, 2001, 26:661-663.
Vanderlugt and Miller, “Epitope spreading in immune-mediated diseases: implications for immunotherapy” Nature Reviews Immunology, 2002, 2:85-95.
Wucherpfenning et al., “Structural basis for MHC-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris” Proc. Natl. Acad. Sci. USA 1995 92:11935-11939.
Veldman et al., “Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and helthy carriers of PV-associated HLA Class II alleles” J. Immunol. 2003, 170:635-642.
Ahmed, A. R., Yunis, E. J., Khatri, K., Wagner, R., Notani, G., Awdeh, Z., & Alper, C. A. (1990). Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with Pemphigus vulgaris. Proc. Natl. Acad. Sci. (USA) 87: 7658.
Ahmed, A. R., Wagner, R., Khatri, K., Notani, G., Awdeh, Z., and Yunis, E. J. (1991). “Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with Pemphigus vulgaris.” Proc. Natl. Acad. Sci. (USA) 88: 5056.
Alexander, J. et al., “Functional Consequences of Engagement of the T Cell Receptor by Low Affinity Ligands,” J. Immunol., 150(1): 1-7 (1993).
Allegretta, M., Nicklas, J. A., Sriram, S. and Albertini, R. J. (1990). “T cells responsive to myelin basic protein in patients with multiple sclerosis.” Science 247: 718-721.
Amagai, M., Klaus-Kovtun, V., & Stanley, J. R. (1991). “Autoantibodies against a novel epithelial cadherin in Pemphigus vulgaris, a disease of cell adhesion.” Cell 67:869-877.
Amagai, M., Karpati, S., Prussick, R., Klaus-Kovtun, V., & Stanley, J. R. (1992). “Autoantibodies against the amino-terminal cadherin-like binding domain of Pemphigus vulgaris antigen are pathogenic.” J. Clin. Invest. 90:919.
Bankier et al., “Sequence Analysis for the 17, 166 Base-pair EcoRI fragment C of B95-8 Epstein-Barr Virus.” Mol. Biol. Med. 1: 21-45 (1983).
Brewerton, D. A., Hart, F. D., Caffrey, M., Nicholls, A., James, D. C. O., & Sturrock, R. D. (1973). “Ankylosing spondylitis and HL-A 27.” Lancet 1: 904.
Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1993). “Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.” Nature 364: 33.
Brown, L.R. et al., “Recognition of the influenza hemaglutinin by class II MHC-restricted T lymphocytes and antibodies, I. Site definition and implications for antigen presentation and T lymphocyte recognition.” J. Immunol., 147(8):2677-2684 (1991).
Busch, R., Hill, C. M., Hayball, J. D., Lamb, J. R., Rothbard, J. B. (1991). “Effect of a natural polymorphism at residue 86 of the HLA-DR .beta. chain on peptide binding.” J. Immunol. 147:1292-1298.
Chambers et al., “Antigenic and Molecular Characterization of Subtype H13 Hemagglutinin of Influenza Virus.” Virology 172: 180-188 (1989).
Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A. A., Lane, W. S., & Strominger, J. L. (1993). “Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.” J. Exp. Med. 178:27.
Chicz, R. Et al., “Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size.” Nature, 358: 764-768 (1992).
Datta, A. K., Feighny, R. J., Pagano, J. S. (1980). “Induction of Epstein-Barr virus-associated DNA polymerase by 12-O-tetradecanoylphorbol-13-acetate.” J. Biol. Chem. 255: 5120-5125.
Dermody et al., “The S2 Gene Nucleotide Sequences of Prototype Strains of the Three Reovirus Serotypes: Characterization of Reovirus Core Protein o2.” J. of Virology 65(11): 5721-5721 (1991).
Epstein, M. A., Achong, B. G. (1977). “Pathogenesis of infectious mononucleosis.” Lancet 11: 1270-1272.
Gregersen, P. K., Silver, J., Winchester, R. J. (1987). “The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.” Arthritis Rheum. 30: 1205-1213.
Hammer, J. et al., “Promiscuous and Allele-Specific Anchors in HLA-DR Binding Peptides.” Cell, 74: 197-203 (1993).
Hogenkamp et al., “Nucleotide Sequence of the Right 10% of Adenovirus Type 12 DNA Encoding the Entire Region E4.” Nucleic Acids Research 18(10): 3065-3066 (1990).
Jardetzky, T. S., Lane, W. S., Robinson, R. A., Madden, D. R., & Wiley, D. C. (1991). “Identification of self-peptides bound to purified HLA-B27.” Nature 353: 326.
Jardetzky, T. S. et al., “Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.” EMBO J., 9(6): 1797-1803 (1990).
Johnson, R. T., Griffin, D. E., Hirsch, J. S., Wolinsky, J. S., Rodenbeck, S., Lindo De Soriano, I. and Vaisberg, A. (1984). “Measles encephalomyelitis. Clinical and immunological studies.” N. Engl. J. Med. 310: 137-141.
Kaufman, D. L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G. S. P., Robinson, P., Atkinson, M. A., Sercarz, E. E., Tobin, A. J., and Lehmann, P. V. (1993). “Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.” Nature 366: 69-72.
Kurtzke, J. F. (1985). “Epidemiology of multiple sclerosis” in Handbook of clinical neurology Eds. P. J. Vinken, G. W. Bruyn, H. L. Klawans and J. C. Koetsier. Amsterdam/New York, Elsevier Sci. 259-287.
Lanchbury, J. S., & Panayi, G. S. (1991). “Genetics of RA: the HLA shared epitope hypothesis and its implications.” Br. J. Rheumatol. 30(Suppl 2): 6.
Lehmann, P. V., Forsthuber, T., Miller, A. and Sercarz, E. E. (1992). “Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen.” Nature 358: 155-157.
Madden, D. R., Gorga, J. C., Strominger, J. L., & Wiley, D. C. (1991). “The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation.” Nature 353: 321.
Madden, D.R. et al., “The Antigenic Identity of Peptide-MHC Complexes: A Comparison of the Conformation of Five Viral Peptides Presented by HLA-A2.” Cell, 75:693-708 (1993).
Marsh, S. G. E. and Bodmer, J. G. (1992). “HLA class II nucleotide sequences, 1992.” Human Immunol. 35: 1-17.
Martin, R., Jaraquemada, D., Flerlage, M., Richert, J., Whitaker, J., Long, E. O., McFarlin, D. E. and McFarland, H. F. (1990). “Fine specificity and HLA restriction of myelin basic protein-spec

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Identification of self and non-self antigens implicated in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification of self and non-self antigens implicated in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of self and non-self antigens implicated in... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3715549

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.