Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-06-07
1998-01-13
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 4, 514 12, C12Q 134, A61K 0000
Patent
active
057078211
ABSTRACT:
The invention provides methods and compositions for treating neurodegeneration in mammalian cells by administering a phospholipase A2 inhibitor.
REFERENCES:
patent: 5137873 (1992-08-01), Yankner
patent: 5281626 (1994-01-01), Oinuma et al.
patent: 5328842 (1994-07-01), Chiou et al.
patent: 5354677 (1994-10-01), Knopf et al.
patent: 5453443 (1995-09-01), Perrier et al.
patent: 5478857 (1995-12-01), Clemens et al.
Eikelenboom, P. et al. "Inflammatory mechanisms in Alzheimer's disease" Trends in Pharm. Sci. 15(12):447-450, (Dec. 1994).
Simmons, L. K. et al. "Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro" Mol. Pharmacol. 45(3):373-379, (Mar. 1994).
Abdullah et al., "Human cytosolic phospholipase A.sub.2 expressed in insect cells is extensively phosphorylated on Ser-505," Biochimica et Biophysica Acta, 1244:157-164 (1995).
Abdullah et al., "Synthesis and Preparation of an Affinity Chromatography Column for the Purification of Cytosolic Phospholipase A.sub.2, " Bioorganic & Medicinal Chemistry Letters, 5(5):519-522 (1995).
Abdullah et al., "Purification of Baculovirus-Overexpressed Cytosolic Phospholipase A.sup.2 Using a Single-Step Affinity Column Chromatography," Protein Expression and Purification, 6:291-297 (1995).
Ackermann et al., "Inhibition of Macrophage Ca.sup.2+ -independent Phospholipase A.sub.2 by Bromoenol Lactone and Trifluoromethyl Ketones," J. Biol. Chem., 270(1):445-450 (1995).
Bartoli et al., "Tight Binding Inhibitors of 85-kDa Phospholipase A.sub.2 but Not 14-kDa Phospholipase A.sub.2 Inhibit Release of Free Arachidonate in Thrombin-stimulated Human Platelets," J. Biol. Chem., 269(22):15625-15630 (1994).
Currie et al., "Phosphorylation and activation of Ca.sup.2+ -sensitive cytosolic phospholipase A.sub.2 in MCII mast cells mediated by high-affinity F.sub.c receptor for IgE," Biochem. J., 304:1-6 (1994).
Dennis, "Diversity of Group Types, Regulation, and Function of Phospholipase A.sub.2," J. Biol. Chem., 269(18):13057-13060 (1994).
Glaser et al., "Phospholipase A.sub.2 enzymes: regulation and inhibition," TiPS, 14:92-98 (1993).
Kramer, "Structure, Function and Regulation of Mammalian Phospholipases A.sub.2," Advances in Second Messenger and Phosphoprotein Research, 28:81-89 (1993).
Lin et al., "cPLA.sub.2 Is Phosphorylated and Activated by MAP Kinase," Cell, 72:269-278 (1993).
Mattson et al., ".beta.-Amyloid precursor protein metabolites and loss of neuronal Ca.sup.2+ homeostasis in Alzheimer's disease," TINS, 16(10):409-414 (1993).
Meda et al., "Activation of microglial cells by .beta.-amyloid protein and interferon-.tau.," Nature, 374:647-650 (1995).
Oinuma et al., "Synthesis and Biological Evaluation of Substituted Benzenesulfonamides as Novel Potent Membrane-Bound Phospholipase A.sub.2 Inhibitors," J. Med. Chem., 34:2260-2267 (1991).
Petit et al., "Isolation and Characterization of a Cytosolic Phospholipase A.sub.2 from Bovine Adrenal Medulla," J. of Neurochem. 64:139-146 (1995).
Reynolds et al., "1-Hexadecyl-2-Arachidonoylthio-2-deoxy-sn-Glycero-3-Phosphorylcholine as a Substrate for Microtiterplate Assay of Human Cytosolic Phospolipase A.sub.2," Anal. Biochem., 217:25-32 (1994).
Reynolds et al, "Assay Strategies and Methods for Phospholipases," Methods in Enzymology, 197:3-23 (1991).
Riendeau et al., "Arachidonyl Trifluoromethyl Ketone, a Potent Inhibitor of 85-kDa Phospholipase A.sub.2, Blocks Production of Arachidonate and 12-Hydroxyeicosa-tetraenoic Acid by Calcium Ionophore-challenged Platelets," J. Biol. Chem., 269(22);15619-15624 (1994).
Roshak et al., "Suppression of Monocyte 85-kDa Phospholipase A.sub.2 by Antisense and Effects on Endotoxin-induced Prostaglandin Biosynthesis," J. Biol. Chem., 269(42):25999-26005 (1994).
Street et al., "Slow- and Tight-Binding Inhibitors of the 85-kDa Human Phospholipase A.sub.2," Biochem., 32:5935-5940 (1993).
Verity, "Mechanisms of Phospholipase A.sub.2 Activation and Neuronal Injury," Annals NY Acad. Sci., 679:110-120 (1993).
Alberts, B. et al. Molecular Biology of the Cell, Second Edition. New York: Garland Publ. 1989, pp. 689-690 and 974.
Dumuis, A. et al. "Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells" Molec. Pharmacol. 43(6):976-981, abstract only, (Jun. 1993).
Dappen Michael S.
Rydel Russell E.
Athena Neurosciences, Inc.
Duvall, Esq. Jean
Lau Kawai
Storella, Esq. John
Wax Robert A.
LandOfFree
Identification of phospholipase A2 inhibitors in A.beta. peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Identification of phospholipase A2 inhibitors in A.beta. peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of phospholipase A2 inhibitors in A.beta. peptide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-325347