Identification of novel antimicrobial agents using membrane pote

Details Identification of novel antimicrobial agents using membrane pote Identification of novel antimicrobial agents using membrane pote

1999-09-24

2000-11-07

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 32, 435 4, 435911, 435968, 549227, 430585, C12Q 102, C12Q 118, C12Q 100

Patent

active

061435163

ABSTRACT:
Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.

REFERENCES:
patent: 4859584 (1989-08-01), Horan et al.
Wang et al., "Susceptibility of Melanized and Nonmelanized Crypotococcus neoformans to the Melanin-Binding Compounds Trifluoperazine and Chloroquine"Antimicrobial Agents and Chemotherapy 40:541-545 (1996).
Abrahamson et al., "Mechanism of Action of XMP Antifungal Peptides: Factors that Influence Activity and Subcellular Localization", Abstract for ICAAC meeting, Sep. 28-Oct. 1, 1997, Toronto, Canada.
Little et al., "XMP Antifungal Peptides Demonstrate Enhanced Selectivity and Oral Availability" Abstract for ICAAC meeting, Sep. 24-27, 1998, San Diego, California.

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