Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-01-06
1990-01-23
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 34, 436548, 436800, 530391, 530809, 935110, G01N 33569, G01N 33577
Patent
active
048957968
ABSTRACT:
A method for distinguishing between NK cells and T lymphocytes is provided, which comprises contacting a sample containing lymphocytes with a first reagent comprising anti-CD3 and a first detectable label and a second reagent comprising a mixture of anti-CD16 and anti-GP160 (Leu-19) both labeled with a second detectable label, and identifying cells that react with the reagents, whereby cells that react with the first reagent are identified as T lymphocytes, and cells that react only with the second reagent are identified as NK cells. Cells that react with both reagents are identified as a unique subset of T lymphocytes some of which may mediate MHC unrestricted cytolysis.
REFERENCES:
patent: 4599304 (1986-07-01), Lanier et al.
patent: 4772552 (1988-09-01), Hercend et al.
Lanier et al, Journ. Immunol., 136, 4480-4486, 1986.
Jackson Anne L.
Lanier Lewis L.
Phillips Joseph H.
Becton Dickinson and Company
Neeley Richard L.
Saunders David A.
Warden Robert J.
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