Identification of methionine N.alpha.-acetyltransferase

Details Identification of methionine N.alpha.-acetyltransferase Identification of methionine N.alpha.-acetyltransferase

1990-10-16

1993-06-29

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435255, 435256, 435803, 435814, 435815, 435942, C12N 910, C12N 118, C12N 1100, C12R 1865

Patent

active

052234215

ABSTRACT:
A methionine N.sup..alpha. -acetyltransferase enzyme has been identified in yeast. The existence of the enzyme defines a gene for methionine N.sup..alpha. -acetyltransferase which may be cloned and altered. Cells expressing the normal or variant forms of this enzyme are valuable tools for determining the amino acid sequence of uncharacterized proteins. Such cells are also valuable tools for expressing a recombinant protein lacking an acetyl group at its .alpha.-amino group.

REFERENCES:
Lee, F-J. S., et al., The Journal of Biological Chemistry 265:3603-3606 (1990).
Tsunasawa, S., et al., The Journal of Biological Chemistry 260:5382-5391 (1985).
Lee, F-J. S. et al., The Journal of Biological Chemistry 263:14948-14955 (1988).
Lee, F-J. S. et al., The Journal of Biological Chemistry 264:12339-12343 (1989).
Tsunasawa, S. et al., Methods In Enzymology 106:165-170 (1984).
Driessen, H. P. C., et al., CRC Critical Reviews in Biochemistry 18:281-325 (1985).
Wold, F., Trends Biochem. Sci. 9:256-257 (1984).
Pestana, A. et al., Biochemistry 14:1404-1412 (1975).
Yamada, R. et al., 1st Sym. Protein Soc. 625:34 (1987).
O'Donohue, T. L., The Journal of Biological Chemistry 258:2163-2167 (1983).
Woodford, T. A. et al., The Journal of Biological Chemistry 254:4993-4999 (1979).
Arfin, S. M., et al., Biochemistry 27:7979-7984 (1988).
Smith, J. A. et al., Banbury Report 28:69-75 (1988).
Kamitani, K. et al., The Journal of Biological Chemistry 264:13188-13193 (1989).
Mullen, J. R. et al., The EMBO Journal 8:2067-2075 (1989).
Lee, F-J. S. et al., Journal of Bacteriology 171:5795-5802 (1989).
Lee, F-J. S. et al., FEBS Lett. 256:139-142 (1989).
Albelda et al. FASEB J. 4:2868-2880 (1990).
Hynes, Cell 49:549-554 (1987).
Ruoslahti, J. Clin. Invest, 87: 1-5 (1991).
Fitzgerald et al., J. Biol. Chem., 262:3936-3939 (1987).
Hogervorst et al., EMBO J., 9:765-770 (1990).
Kishimoto et al., Cell, 48:681-690 (1987).
McLean et al., J. Biol. Chem., 265:17126-17131 (1990).
Ramaswamy et al., EMBO J. 9:1561-1568 (1990).
Sheppard et al., J. Biol. Chem, 265:11502-11507 (1990).
Suzuki and Naitoh, EMBO J. 9:757-763 (1990).
Tamkun et al., Cell 46:271-282 (1986).
Yuan et al., Intl. Immunol., 2:1097-1108 (1990).
Halten et al., Trends. Neurol. Sci., 13:179-184 (1990).
Jessell, Neuron, 1:3-13 (1988).
Sanes, Ann. Rev. Neurosci, 12:491-516 (1989).
Plantefaber and Hynes Cell, 56:281-290 (1989).
Saga et al., Cancer Res., 48:5510-5513 (1988).
Bodary and McLean, J. Biol. Chem., 265:5938-5941 (1990).
Fitzgerald and Phillips, Molecular Biology, Immunology, Biochemistry and Pathology pp. 387-418 (Alan R. Liss, NY 1988).
Hemler, Ann Rev. Immunol., 8:365-400 (1990).
Horton, Int. Exp. Pathol., 71:741-759 (1990).
Kieffer and Phillips Ann. Rev. Cell Biol., 6:329-357 (1990).
Kajiji et al., EMBO J, 8(3):673-680 (1989).
Phillips et al., Blood, 71(4):831-843 (1988).
Bossy et al., Biochemistry, 29:10191-10198 (1990).
Chuong, Experientia, 46:892-899 (1990).
Rathgen et al., Trends in Neurosciences 11(5):183-184 (1988).

Affiliated with

Also associated with

Rating

Identification of methionine N.alpha.-acetyltransferase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification of methionine N.alpha.-acetyltransferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of methionine N.alpha.-acetyltransferase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1754738