Identification of kinase inhibitors

Details Identification of kinase inhibitors Identification of kinase inhibitors

2007-04-10

2007-04-10

Shibuya, Mark L. (Department: 1639)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C530S350000

Reexamination Certificate

active

10394322

ABSTRACT:
The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using a covalent tethering approach to identify inhibitors preferentially targeting the inactive conformation.

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