Identification of Hla-A2-presented T-cell epitopes derived...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C530S328000, C530S327000, C530S326000, C530S325000, C530S350000, C536S023500, C435S320100, C435S069100, C435S372300

Reexamination Certificate

active

07968097

ABSTRACT:
The present invention relates to the immunotherapB of cancer, in particular several tumor entities including hematological malignancies. The present invention relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class I or II molecules of human oncofoetal antigen immature laminin receptor (OFA/iLR), which can be used in vaccine compositions for eliciting anti-tumor immune responses.

REFERENCES:
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patent: WO 2004012681 (2004-02-01), None
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Database Uniprot [Online] Nov. 1996, “Potential Laminin-Binding Protein (Fragment).” XP002344539 Retrieved From EBI Accession No. Uniprot: Q29231—PIG Database Accession No. Q29231 Amino Acid Sequence.
A. K. Wintero et al: “Evaluation and Characterization of a Porcine Small Instestine CDNA Library: Analysis of 839 Clones.” Mammalian Genome: Official Journal of the International Mammalian Genome Society. Jul. 1996, vol. 7, No. 7, Jul. 1996, pp. 509-517 ISSN: 0938-8990.
Database Uniprot [Online] Aug. 1992, “40S Ribosomal Protein SA (P40) (C10 Protein).” XP002364021 Retrieved From EBI Accession No. Uniprot: RSSA—Bovin Database Accession No. P26452 Sequence.
Database Uniprot [Online] Oct. 1, 1996, “40S Ribosomal Protein SA (P40) (34/67 KDA Laminin Receptor) (37LRP).” XP002364022 Retrieved From EBI Accession No. Uniprot: RSSA—Chick Database Accession No. P508950 Sequence.
International Search Report for PCT/EP2006/003888 Dated Sep. 7, 2006.
Sandra Siegel et al. “Identification of HLA-A 0201-Presented T Cell Epitopes Derived From the Oncofetal Antigen-Immature Laminin Receptor Protein in Patients With Hematological Malignancies” Journal of Immunology, 2006, 176: 6935-6944.
Database Geneseq [Online] Jan. 29, 2003, “Human Expressed Protein TAG (EPT) #1444.” XP002387968 Retrieved From EBI Accession No. GSN: ABU04778. Database Accession No. ABU04778.
Database Geneseq [Online] Jan. 29, 2003, “Human Expressed Protein TAG (EPT) #1335.” XP002387969, Retrieved From EBI Accession No. GSP: ABU04669; Database Accession No. ABU04669.

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