Identification of Free-B-Ring flavonoids as potent COX-2...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10469275

ABSTRACT:
The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5443983 (1995-08-01), OChoa et al.
patent: 5643598 (1997-07-01), Maybeck
patent: 5756538 (1998-05-01), Cassels et al.
patent: 5858371 (1999-01-01), Singh et al.
patent: 6083921 (2000-07-01), Xu
patent: 6217875 (2001-04-01), Murai et al.
patent: 6235294 (2001-05-01), Perrier et al.
patent: 6264995 (2001-07-01), Newmark et al.
patent: 6290995 (2001-09-01), Xinxian
patent: 6387416 (2002-05-01), Newmark et al.
patent: 6391346 (2002-05-01), Newmark et al.
patent: 2002/0086070 (2002-07-01), Kuhrts
patent: 2002/0122836 (2002-09-01), Obukowicz et al.
patent: 2002/0136784 (2002-09-01), Obukowicz et al.
patent: 1096680 (1994-12-01), None
patent: 1285202 (2001-02-01), None
Kubo et al., Chem. Pharm. Bull., vol. 32, 1984, pp. 2724-2729.
Yamahara et al., Shoyakugaku Zasshi, 1981, 35(2), abstract.
Kikukawa et al., Ensho, 1995, 15(2), abstract.
Butenko et al., Agents Actions, 39, Special Conference issue, 1993, C49-C51.
Chung et al. Pharmacological Effects of Methanolic Extract from the Root ofScutellaria baicalensisand its Flavonoids on Human Gingival Fibroblast, (Apr. 1995) 61:150-153 Planta Med.(NY).
Chen et al.Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation, (Jun. 1, 2000) 59(11):1445-1447 Biochemical Pharmacology.
Kim et al. (1990) Yakhak Hoeji 34(5):348-364.
Afolayan and Meyer (1997) Journal of Ethnopharmacol. 57(3):177-181.
Ardlie et al. (1985) Thromb. Res. 38(6):695-706.
Boumendjel et al. (2001) Bioorg. Med. Chem. Lett. 11(1):75-77.
Brideau et al. (1996) Inflamm. Res. 45:68-74.
Chen et al. (2001) Biochem. Pharmacol. 61(11):1417-1427.
Chi et al. (2001) Biochem. Pharmacol. 61:1195-1203.
Commenges et al. (Apr. 2000) Eur. J. Epidemiol 16:357-363 (Abstract).
Heo et al. (2001) Mutat. Res. 488(2):135-150.
Imamura et al. (2000) J. Biochem. 127(4):653-658.
Itoigawa et al. (1999) J. Ethnopharmacol. 65(3): 267-272.
Kalkbrenner et al. (1992) Pharmacology 44(1):1-12.
Kaneko and Baba (1999) Biosci Biotechnol. Biochem 63(2):323-328.
Kimura et al. (2001) Planta Med. 67:331-334.
Krakauer et al. (2001) FEBS Lett. 500:52-55.
Kubo et al. (2000) Bioorg. Med. Chem. 8(7):1749-1755.
Li et al. (2000) Immunopharmacology 49:295-306.
Liang et al. (2001) FEBS Lett. 496(1):12-18.
Meyer et al. (1997) J. Ethnopharmacol. 56(2):165-169.
Moroney et al. (1988) J. Pharm. Pharmacol. 40:787-792.
Mutoh et al. (Jul. 2000) Jnp. J. Cancer Res. 91:686-691 (abstract).
Nakahata et al. (1998) Am. J. Chin Med. 26:311-323 (abstract).
Nakahata et al. (1999) Nippon Yakurigaku Zasshi, 114, Supp. 11:215P-219P.
Nakajima et al. (2001) Planta Med. 67(2):132-135.
Raso et al. (2001) Life Sci. 68(8):921-931.
de la Puerta et al. (1999) Planta Medica 65:507-511.
Salmon et al. (1985) Prostaglandins 29(3):377-385.
So et al. (1997) Cancer Lett. 112(2):127-133.
Sobottka et al. (2000) Arch. Pharm. Pharm. Med. Chem. 333:205-210.
Tordera et al. (1994) Z. Naturforsch [C] 49:235-240 (abstract).
Wakabayashi and Yasui (2000) Eur. J. Pharmacol. 406(3):477-481.
de Whalley et al. (1990) Biochemical Pharmacology 39:1743-1750.
Wang (2000) Phytomedicine 7:15-19 (abstract).
Wenzel et al. (Jul. 2000) Cancer Res. 60:3823-3831.
You et al. (1999) Arch. Pharm. Res. 22(1):18-24 (abstract).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Identification of Free-B-Ring flavonoids as potent COX-2... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification of Free-B-Ring flavonoids as potent COX-2..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of Free-B-Ring flavonoids as potent COX-2... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3789880

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.