Identification of differentiation factor receptors which inhibit

Details Identification of differentiation factor receptors which inhibit Identification of differentiation factor receptors which inhibit

1994-09-21

1998-08-04

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

514 44, 4352402, 43524025, 435 691, 935 62, C12Q 102, A61K 3170, C12N 1512

Patent

active

057891877

ABSTRACT:
Disclosed is a method of reducing or inhibiting the tumorigenicity of a tumor cell in which a vector including a nucleotide sequence encoding a differentiation factor receptor, or a polypeptide portion thereof, is transferred to the tumor cell such that the nucleotide sequence is expressed. Tumorigenicity is monitored by cell growth and colony formation in a semi-soft medium, a reduction in proliferation being indicative of the reduction or inhibition of tumorigenicity of the treated tumor cell.

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