Identification of compounds for modulating dimeric receptors

Details Identification of compounds for modulating dimeric receptors Identification of compounds for modulating dimeric receptors

2007-02-20

2007-02-20

Moran, Marjorie A. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Chemical analysis

C702S019000, C702S022000

Reexamination Certificate

active

09744628

ABSTRACT:
The invention includes the fitted quaternary structure of insulin receptor. It also includes methods of identifying compounds that modulate insulin receptor activity by producing a compound that interacts with all or part of the fitted quaternary structure of insulin receptor or a fragment or derivative thereof and which thereby modulates insulin receptor activity.

REFERENCES:
patent: 4761371 (1988-08-01), Bell et al.
patent: 5646242 (1997-07-01), Baker et al.
patent: 5693609 (1997-12-01), Baker et al.
patent: 5700662 (1997-12-01), Chance et al.
patent: WO 09/32017 (1998-07-01), None
patent: WO 99/28347 (1999-06-01), None
Lauri et al. (Journal of Computer-Aided Molecular Design (1994) vol. 8, pp. 51-66).
Christiansen et al. (PNAS (1991) vol. 88, pp. 249-252).
Luo, R., “Quaternary Structure of the Insulin-Insulin Receptor Complex”,Science, 285:1077-1080 (1999).
McInnes, C., “Growth Factor Receptors: Structure, Mechanism, and Drug Discovery”,Biopolymers43(5):339-366 (1997) XP000972110.
Olsen, H., “The Relationship Between Insulin Bioactivity and Structure in the NH2-terminal A-chain Helix”,J. Mol. Biol. 284:477-488 (1998) XP000965558.
F.P. Ottensmeyer, R. Z-T Luo, A.B. Fernandes, D. Beniac and C.C. Yip, “Insulin Receptor: 3D Reconstruction From Darkfield Stem Images, Structural Interpretation and Functional Model,” Proceedings of the Microscopial Society of Canada, 26th Annual Meeting, May 26-28, 1999, University of Guelph, Guelph, Ontario, Canada.
F.P. Ottensmeyer, Daniel R. Beniac, Robert Z-T. Luo & Cecil C. Yip, “The Insulin Receptor: Structure, Ligand Binding and Mechanics of Transmembrane Signalling,” Protein Engineering Network of Centres of Excellence Seminar, University of Toronto, Dec. 16, 1999, Toronto, Ontario, Canada.
F.P. Ottensmeyer, Daniel R. Beniac, Robert Z.-T. Luo and Cecil C. Yip, “Mechanism of Transmembrane Signaling: Insulin Binding and the Insulin Receptor,” Biochemistry, vol. 39, No. 40, Oct. 10, 2000.
Lilli Petruzzelli, Roman Herrera and Ora M. Rosen, “Insulin receptor is an insulin-dependent tyrosine protein kinase: Copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta,” Proc. Natl. Acad. Sci. USA, vol. 81, pp. 3327-3331, Jun. 1984, Biochemistry.
Melanie H. Cobb and Ora M. Rosen, “The Insulin Receptor and Tyrosine Protein Kinase Activity,” Biochimica et Biophysica Acta, 738 (1984) 1-8.
A. Ullrich et al., “Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells,” Nature, vol. 309, pp. 418-425, May 1984.
J. Downward et al., “Close similarity of epidermal growth factor and v-erb-B oncogene protein sequences,” Nature, vol. 307, pp. 521-527, Feb. 1984.
Todd W. Siegel et al., “Purification and Properties of the Human Placental Insulin Receptor,” The Journal of Biological Chemistry, vol. 256, No. 17, Issue of Sep. 10, pp. 9266-9273, 1981.
George L. King et al., “Synthesis and Characterization of Molecular Hybrids of Insulin and Insulin-like Growth Factor I,” The Journal of Biological Chemistry, vol. 257, No. 18, pp. 10869-10873, Sep. 1982.
C.C. Yip and P. Ottensmeyer. “Three-dimensional Structural Interactions of Insulin and its Receptor.” J. Biol. Chem. 278:27329-27332, 2003.
C. Tan et al. “Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.” Bioorganic & Medicinal Chemistry Letters, vol. 14: 1407-1410, 2004.
“Insulin-like growth factor I receptor precursor (CD221 antigen)”, P08069. Created: Aug. 1, 1988, Sequence updated: Aug. 1, 1988. Annotation updated: Mar. 15, 2004.

Affiliated with

Also associated with

Rating

Identification of compounds for modulating dimeric receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Identification of compounds for modulating dimeric receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Identification of compounds for modulating dimeric receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3885988