Identification of cell culture contaminants among Mollicutes...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S006120, C435S091200

Reexamination Certificate

active

07872116

ABSTRACT:
The present invention encompasses nucleic acids, methods, compositions, and kits for sensitive, rapid and specific detection ofMycoplasma, Acholeplasma, Ureaplasma, PhytoplasmaandSpiroplasmaspecies in a sample. The invention utilizes specific primers and amplification methods that permit differentiation between species due to specific amplification of target nucleic acids of contaminating Mollicute cells. In one embodiment, the invention utilizes the differing melting temperatures (Tm) of various potential PCR products to identify whether they are specific target amplification products, non-specific, non-target amplification products, specific positive control products, or primer-dimer products.

REFERENCES:
patent: 7202027 (2007-04-01), Grabowski et al.
patent: 2005/0250112 (2005-11-01), Padmabandu et al.
patent: WO 0123606 (2001-04-01), None
Volokhov, D.V. et al. Sequencing of the intergenic 16S-23S rRNA spacer (ITS) region of Mollicutes species and their identification using microarray-based assay and DNA sequencing. Appl. Microbiol. Biotechnol., vol. 71, pp. 680-698, published on line 10, Feb. 2006.
Lowe et al., A computer program for selection of oligonucleotide primers for polymerase chain reactions. Nucleic Acids Research, vol. 18, No. 7, pp. 1757-1761, 1990.

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